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GSK2982772

Name: GSK2982772
Brand: TargetMol
SKU: T7151
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7151Cas No. 1622848-92-3

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.

GSK2982772

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Purity: 99.31%

Catalog No. T7151Cas No. 1622848-92-3

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$150	In Stock
10 mg	$231	In Stock
25 mg	$393	In Stock
50 mg	$545	In Stock
100 mg	$737	In Stock
1 mL x 10 mM (in DMSO)	$125	In Stock

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Purity:99.31%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
Targets&IC50	RIP1 (monkey):20 nM, RIP1 (human):16 nM
In vitro	GSK2982772 ?potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking many TNF-dependent cellular responses.?Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants.

Chemical Properties

Molecular Weight	377.4
Formula	C₂₀H₁₉N₅O₃
Cas No.	1622848-92-3
Smiles	CN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (264.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6497 mL	13.2485 mL	26.4971 mL	132.4854 mL
5 mM	0.5299 mL	2.6497 mL	5.2994 mL	26.4971 mL
10 mM	0.2650 mL	1.3249 mL	2.6497 mL	13.2485 mL
20 mM	0.1325 mL	0.6624 mL	1.3249 mL	6.6243 mL
50 mM	0.0530 mL	0.2650 mL	0.5299 mL	2.6497 mL
100 mM	0.0265 mL	0.1325 mL	0.2650 mL	1.3249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc