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VA-K-14 hydrochloride

🥰Excellent
Catalog No. T29087Cas No. 1171341-19-7
Alias VAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HCl

VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

VA-K-14 hydrochloride

VA-K-14 hydrochloride

🥰Excellent
Purity: 97.15%
Catalog No. T29087Alias VAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HClCas No. 1171341-19-7
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$54In StockIn Stock
5 mg$127In StockIn Stock
10 mg$196In StockIn Stock
25 mg$396In StockIn Stock
50 mg$645In StockIn Stock
100 mg$987In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:97.15%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
Targets&IC50
TSHR:12.3 μM
SynonymsVAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HCl
Chemical Properties
Molecular Weight341.86
FormulaC18H16ClN3S
Cas No.1171341-19-7
SmilesCl.CNc1nc(cs1)-c1c([nH]c2ccccc12)-c1ccccc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (160.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9252 mL14.6259 mL29.2517 mL146.2587 mL
5 mM0.5850 mL2.9252 mL5.8503 mL29.2517 mL
10 mM0.2925 mL1.4626 mL2.9252 mL14.6259 mL
20 mM0.1463 mL0.7313 mL1.4626 mL7.3129 mL
50 mM0.0585 mL0.2925 mL0.5850 mL2.9252 mL
100 mM0.0293 mL0.1463 mL0.2925 mL1.4626 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

VAK-14 HydrochlorideVA-K-14 HydrochlorideVAK 14 HydrochlorideTSHReceptorTSH Receptorthyrotropin receptor (TSHR)
Related Tags: buy VA-K-14 hydrochloride | purchase VA-K-14 hydrochloride | VA-K-14 hydrochloride cost | order VA-K-14 hydrochloride | VA-K-14 hydrochloride chemical structure | VA-K-14 hydrochloride formula | VA-K-14 hydrochloride molecular weight
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