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VA-K-14 hydrochloride

Name: VA-K-14 hydrochloride
Brand: TargetMol
SKU: T29087
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29087Cas No. 1171341-19-7

Alias VAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HCl

VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

VA-K-14 hydrochloride

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Purity: 99.37%

Catalog No. T29087Alias VAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HClCas No. 1171341-19-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
5 mg	$127	In Stock	In Stock
10 mg	$196	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$645	In Stock	In Stock
100 mg	$987	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.37%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
Targets&IC50	TSHR:12.3 μM
Synonyms	VAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HCl

Chemical Properties

Molecular Weight	341.86
Formula	C₁₈H₁₆ClN₃S
Cas No.	1171341-19-7
Smiles	Cl.CNc1nc(cs1)-c1c([nH]c2ccccc12)-c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (160.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9252 mL	14.6259 mL	29.2517 mL	146.2587 mL
5 mM	0.5850 mL	2.9252 mL	5.8503 mL	29.2517 mL
10 mM	0.2925 mL	1.4626 mL	2.9252 mL	14.6259 mL
20 mM	0.1463 mL	0.7313 mL	1.4626 mL	7.3129 mL
50 mM	0.0585 mL	0.2925 mL	0.5850 mL	2.9252 mL
100 mM	0.0293 mL	0.1463 mL	0.2925 mL	1.4626 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc