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Anxiolytic/nonsedative agent-1
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Catalog No. T23445Cas No. 355022-97-8
Alias TCS 1205
Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo.
Anxiolytic/nonsedative agent-1
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Purity: 98.61%
Catalog No. T23445Alias TCS 1205Cas No. 355022-97-8
Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $58 | In Stock | In Stock | |
| 2 mg | $88 | In Stock | In Stock | |
| 5 mg | $117 | In Stock | In Stock | |
| 10 mg | $153 | In Stock | In Stock | |
| 25 mg | $348 | In Stock | In Stock | |
| 50 mg | $497 | In Stock | In Stock | |
| 100 mg | $690 | In Stock | In Stock | |
| 500 mg | $1,360 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.61%
Appearance:Solid
Color:Yellow
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Product Introduction
Anxiolytic/nonsedative agent-1 AI Summary
Anxiolytic/nonsedative agent-1 exhibits bioactivities related to the modulation of GABA-A receptor subunits and benzodiazepine receptors. It shows potent inhibitory effects on [3H]-flumazenil binding to benzodiazepine receptors in bovine brain membranes and on rat alpha-1-beta-2-gamma-2 GABA-A receptor subunits expressed in HEK293 cells, with Ki values ranging from 14.0 nM to 239.0 nM for different receptor subtypes. The compound also demonstrates weaker inhibition on rat alpha-3-beta-2-gamma-2 and alpha-5-beta-3-gamma-2 GABA-A receptor subunits. Additionally, it functions as an agonist, promoting chloride influx with activities of 35.0% and 79.0% for specific receptor combinations. These findings suggest that Anxiolytic/nonsedative agent-1 may modulate inhibitory neurotransmission, potentially offering therapeutic implications in neurological or psychiatric conditions by exhibiting anxiolytic or sedative effects. The ratios of Ki with and without GABA indicate a moderate modulation of receptor activity in the presence of this neurotransmitter..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo. |
| Synonyms | TCS 1205 |
| Molecular Weight | 337.33 |
| Formula | C18H15N3O4 |
| Cas No. | 355022-97-8 |
| Smiles | C(C(N[C@H](C)C1=CC=CC=C1)=O)(=O)C=2C=3C(NC2)=CC=C(N(=O)=O)C3 |
| Relative Density. | 1.373 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.96 mM), Sonication is recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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