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LY2922470

Name: LY2922470
Brand: TargetMol
SKU: T15810
Price: 105 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15810Cas No. 1423018-12-5

LY2922470 is a potent, selective G protein-coupled receptor 40 (GPR40) agonist, with EC50s of 7 nM for human GPR40, 1 nM for mouse GPR40 and 3 nM for rat GPR40, respectively. LY2922470 reduces glucose levels along and increases insulin and GLP-1 significantly.

LY2922470

🥰Excellent

Purity: 97.08%

Catalog No. T15810Cas No. 1423018-12-5

Pack Size	Price	Availability
1 mg	$105	In Stock
5 mg	$249	In Stock
10 mg	$373	In Stock
25 mg	$649	In Stock
50 mg	$926	In Stock
100 mg	$1,260	In Stock
200 mg	$1,690	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock

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Purity:97.08%

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COA LCMS

Product Introduction

Bioactivity

Description	LY2922470 is a potent, selective G protein-coupled receptor 40 (GPR40) agonist, with EC50s of 7 nM for human GPR40, 1 nM for mouse GPR40 and 3 nM for rat GPR40, respectively. LY2922470 reduces glucose levels along and increases insulin and GLP-1 significantly.
Targets&IC50	FFA1/GPR40:3 nM(EC50,rat), FFA1/GPR40:7 nM(EC50, human), FFA1/GPR40:1 nM(EC50,mouse)

Chemical Properties

Molecular Weight	475.6
Formula	C₂₈H₂₉NO₄S
Cas No.	1423018-12-5
Smiles	COc1cccc2CCCN(Cc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)s3)c12
Relative Density.	1.247 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (262.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1026 mL	10.5130 mL	21.0261 mL	105.1304 mL
5 mM	0.4205 mL	2.1026 mL	4.2052 mL	21.0261 mL
10 mM	0.2103 mL	1.0513 mL	2.1026 mL	10.5130 mL
20 mM	0.1051 mL	0.5257 mL	1.0513 mL	5.2565 mL
50 mM	0.0421 mL	0.2103 mL	0.4205 mL	2.1026 mL
100 mM	0.0210 mL	0.1051 mL	0.2103 mL	1.0513 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc