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Aurachin D

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Catalog No. T80016Cas No. 108354-13-8

Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase, acts as an antibiotic against malaria, Plasmodium spp, T. cruzi and Leishmania donovani, can be used to study visceral leishmaniasis.

Aurachin D

Aurachin D

😃Good
Catalog No. T80016Cas No. 108354-13-8
Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase, acts as an antibiotic against malaria, Plasmodium spp, T. cruzi and Leishmania donovani, can be used to study visceral leishmaniasis.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase, acts as an antibiotic against malaria, Plasmodium spp, T. cruzi and Leishmania donovani, can be used to study visceral leishmaniasis.
Chemical Properties
Molecular Weight363.54
FormulaC25H33NO
Cas No.108354-13-8
SmilesO=C1C=2C(NC(C)=C1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)=CC=CC2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (110.03 mM), Sonication and heating are recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 4 mg/mL (11 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7507 mL13.7536 mL27.5073 mL137.5364 mL
5 mM0.5501 mL2.7507 mL5.5015 mL27.5073 mL
10 mM0.2751 mL1.3754 mL2.7507 mL13.7536 mL
20 mM0.1375 mL0.6877 mL1.3754 mL6.8768 mL
50 mM0.0550 mL0.2751 mL0.5501 mL2.7507 mL
100 mM0.0275 mL0.1375 mL0.2751 mL1.3754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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