Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT<I590≈R592A≈W588A. This compound’s C1 domain shares homology in sequence and structure with protein kinase C (PKC), and its activation preference follows the order of PKCα<Munc13-1<PKCε. JH-131e-153 is implicated in the modulation of neuronal processes and holds potential for research in neurodegenerative diseases [1].
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Description | JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈R592A≈W588A. This compound’s C1 domain shares homology in sequence and structure with protein kinase C (PKC), and its activation preference follows the order of PKCα>Munc13-1>PKCε. JH-131e-153 is implicated in the modulation of neuronal processes and holds potential for research in neurodegenerative diseases [1]. |
In vitro | Munc13-1 is a target of the diacylglycerol (二酰甘油) second messenger pathway, functioning during vesicle maturation in the exocytosis (胞吐作用) process. |
Molecular Weight | 382.53 |
Formula | C22H38O5 |
CAS No. | 742104-91-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JH-131e-153 742104-91-2 inhibitor inhibit