Ivaltinostat

Name: Ivaltinostat
Brand: TargetMol
SKU: T14936
Rating: 4.5 (1 reviews)

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Catalog No. T14936Cas No. 936221-33-9

Alias CG-200745

CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.

Ivaltinostat

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Catalog No. T14936Alias CG-200745Cas No. 936221-33-9

CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.

Pack Size	Price	Availability
25 mg	$1,670	6-8 weeks
50 mg	$2,180	6-8 weeks
100 mg	$2,800	6-8 weeks

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Product Introduction

Bioactivity

Description	CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
In vitro	CG200745 induces the accumulation of p53. It promotes p53-dependent transactivation, and it also enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins [1,2]. CG-200745 (0-10 μM; 48 hours) reduces the Calu6 cells proliferation to 40% of untreated cells. CG-200745 (0-10 μM; 1-24 hours) treatment with low concentration significantly increases the acetylation of histone H3 and H4 in Calu6 cells at various sites in a time-dependent manner up to 24 hours after treatment. CG-200745 (3 μM; 1-24 hours) significantly increases Calu6 cells proportion in the G2/M phase (69%) [3].
In vivo	CG-200745 (p.o.; 30?mg/kg/day; for 7 days) weaken inflammatory cytokines, adhesion molecules, oxidative stress in UUO kidneys [4].
Synonyms	CG-200745

Chemical Properties

Molecular Weight	427.54
Formula	C₂₄H₃₃N₃O₄
Cas No.	936221-33-9
Relative Density.	1.148±0.06 g/cm3 (20 °C, 760 mmHg)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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