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Myclobutanil

Name: Myclobutanil
Brand: TargetMol
SKU: T2199
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2199Cas No. 88671-89-0

Alias Systhane

Myclobutanil (Systhane) is a triazole chemical used as a fungicide. It is a steroid demethylation inhibitor, specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component of fungal cell membranes.

Myclobutanil

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Purity: 99.39%

Catalog No. T2199Alias SysthaneCas No. 88671-89-0

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	-
100 mg	$40	In Stock	-
500 mg	$98	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.39%

Color:White

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COA LCMS HNMR

Product Introduction

Myclobutanil AI Summary

Myclobutanil is a small molecule exhibiting bioactivity across various signaling pathways, including peroxisome proliferator-activated receptor gamma, aryl hydrocarbon receptor, p53, antioxidant response element (ARE), and pregnane X receptor (PXR) pathways. Potencies in these pathways range from 100.0 nM to 56234.1 nM. In agricultural applications, it shows antifungal activity against Diaporthe ampelina in grape plants, with effectiveness spanning 0.1% to 68.7% in controlling the fungal infection. It is also effective against Macrophomina phaseolina with a 45.0% disease incidence reduction and an ED50 of 0.26 mg/kg for mycelial growth inhibition. However, it demonstrates phytotoxicity, inhibiting growth in Lagenaria siceraria and squash rootstock seedlings by 33.0%, and shows fungicidal activity against various plant pathogens, such as Podosphaera xanthii, with effectiveness up to 65.1%. As a pesticide, Myclobutanil targets pests on green bean leaves, causing 5.0% to 272.0% mortality depending on the species and concentration. Furthermore, it is effective against Podosphaera aphanis with MIC values under 0.1 ug/mL to 31.0 ug/mL and EC50 values ranging from 0.5 ug/mL to 14.67 ug/mL, highlighting its broad-spectrum antifungal capabilities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Myclobutanil (Systhane) is a triazole chemical used as a fungicide. It is a steroid demethylation inhibitor, specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component of fungal cell membranes.
Synonyms	Systhane

Chemical Properties

Molecular Weight	288.78
Formula	C₁₅H₁₇ClN₄
Cas No.	88671-89-0
Smiles	CCCCC(Cn1cncn1)(C#N)c1ccc(Cl)cc1
Relative Density.	1.2. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (173.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4628 mL	17.3142 mL	34.6284 mL	173.1422 mL
5 mM	0.6926 mL	3.4628 mL	6.9257 mL	34.6284 mL
10 mM	0.3463 mL	1.7314 mL	3.4628 mL	17.3142 mL
20 mM	0.1731 mL	0.8657 mL	1.7314 mL	8.6571 mL
50 mM	0.0693 mL	0.3463 mL	0.6926 mL	3.4628 mL
100 mM	0.0346 mL	0.1731 mL	0.3463 mL	1.7314 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc