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Nidanilimab
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Catalog No. T76873Cas No. 2171061-85-9
Alias Nadunolimab, CAN04
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. It exhibits antitumor activity by disrupting the IL1α and IL1β signaling pathways and inducing the immune system to destroy tumor cells. Nidanilimab can be used to study solid cancers, such as non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).
Nidanilimab
Nidanilimab
😃Good
Catalog No. T76873Alias Nadunolimab, CAN04Cas No. 2171061-85-9
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. It exhibits antitumor activity by disrupting the IL1α and IL1β signaling pathways and inducing the immune system to destroy tumor cells. Nidanilimab can be used to study solid cancers, such as non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $243 | In Stock | In Stock | |
| 5 mg | $753 | In Stock | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,750 | - | In Stock | |
| 50 mg | $2,350 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. It exhibits antitumor activity by disrupting the IL1α and IL1β signaling pathways and inducing the immune system to destroy tumor cells. Nidanilimab can be used to study solid cancers, such as non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC). |
| Targets&IC50 | MC38 colon cancer cells (mouse):1 nM(EC50) |
| In vitro | Nidanilimab (CAN04; 20 µg/mL) exhibits antibody-dependent cell-mediated cytotoxicity (ADCC) with glycoengineering-enhanced properties in mouse MC38 colon cancer cells, with an EC50 of less than 1 nM[2]. Nidanilimab (20 µg/mL) blocks the IL1α and IL1β signaling pathways in mouse MC38 colon cancer cells, with IC50 values of 3.9 nM and 4.1 nM, respectively[2]. |
| In vivo | In nude C57Bl/6 mice, Nidanilimab (CAN04; 10 mg/kg; intraperitoneal injection) enhances the efficacy of two commonly used platinum-based chemotherapy drugs, cisplatin with gemcitabine and carboplatin with gemcitabine[1]. |
| Synonyms | Nadunolimab, CAN04 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-1RAP/IL-1R3 Protein (Fc) at 2 μg/mL (30 μL/well) can bind Nidanilimab. The EC50 is 19.97 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-1RAP/IL-1R3 |
| Molecular Weight | 150 kDa |
| Cas No. | 2171061-85-9 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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