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Nidanilimab

Catalog No. T76873 CAS 2171061-85-9

Synonyms: CAN04

Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destroy tumor cells. Nidanilimab can be used to study solid cancers such as non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).

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Nidanilimab

Nidanilimab, CAS 2171061-85-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 755.00
10 mg	In stock	$ 1,180.00

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Description	Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destroy tumor cells. Nidanilimab can be used to study solid cancers such as non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).
Targets&IC50	MC38 colon cancer cells (mouse):1 nM(EC50)
In vitro	Nidanilimab (CAN04; 20 µg/mL) exhibits antibody-dependent cell-mediated cytotoxicity (ADCC) with glycoengineering-enhanced properties in mouse MC38 colon cancer cells, with an EC50 of less than 1 nM[2]. Nidanilimab (20 µg/mL) blocks the IL1α and IL1β signaling pathways in mouse MC38 colon cancer cells, with IC50 values of 3.9 nM and 4.1 nM, respectively[2].
In vivo	In nude C57Bl/6 mice, Nidanilimab (CAN04; 10 mg/kg; intraperitoneal injection) enhances the efficacy of two commonly used platinum-based chemotherapy drugs, cisplatin with gemcitabine and carboplatin with gemcitabine[1].

Synonyms	CAN04
Molecular Weight	N/A
CAS No.	2171061-85-9

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References and Literature

1. Millrud CR, et, al. The anti-IL1RAP antibody CAN04 increases tumor sensitivity to platinum-based chemotherapy. 2. Rydberg Millrud C, et, al. Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy. Cancer Immunol Immunother. 2022 Aug 29.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nidanilimab 2171061-85-9 Immunology/Inflammation IL Receptor CAN 04 CAN-04 CAN04 inhibitor inhibit

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