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Uplarafenib

Name: Uplarafenib
Brand: TargetMol
SKU: T63333
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63333Cas No. 1425485-87-5

Alias B-Raf IN 10

Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 of 50-100 nM. B-Raf IN 10 exhibits antitumor activity that may influence cell proliferation and differentiation, making it suitable for studying solid tumors.

Uplarafenib

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Purity: 99.98%

Catalog No. T63333Alias B-Raf IN 10Cas No. 1425485-87-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$128	-	In Stock
10 mg	$188	-	In Stock
25 mg	$398	-	In Stock
50 mg	$598	-	In Stock
100 mg	$1,030	-	In Stock
1 mL x 10 mM (in DMSO)	$141	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 of 50-100 nM. B-Raf IN 10 exhibits antitumor activity that may influence cell proliferation and differentiation, making it suitable for studying solid tumors.
In vitro	Uplarafenib (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E [1]. Uplarafenib shows an IC 50 between 50 and 100 nM against BRAF, and less than 50 nM against BRAF V600E.[1] Uplarafenib (72 h) inhibits A375 and SK-MEL-28 cell growth but not CHL-1 and SK-MEL-31 cells [1]. Cell Viability Assay.[1] Cell Line: A375, SK-MEL-28, SK-MEL-31, and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
Synonyms	B-Raf IN 10

Chemical Properties

Molecular Weight	494.49
Formula	C₂₂H₂₁F₃N₄O₄S
Cas No.	1425485-87-5
Smiles	CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)c2ccc3ncc(nc3c2)N2CCOCC2)c1F

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (182.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0223 mL	10.1114 mL	20.2229 mL	101.1143 mL
5 mM	0.4045 mL	2.0223 mL	4.0446 mL	20.2229 mL
10 mM	0.2022 mL	1.0111 mL	2.0223 mL	10.1114 mL
20 mM	0.1011 mL	0.5056 mL	1.0111 mL	5.0557 mL
50 mM	0.0404 mL	0.2022 mL	0.4045 mL	2.0223 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc