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Uplarafenib

Catalog No. T63333 CAS 1425485-87-5

Synonyms: B-Raf IN 10

Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study solid tumors.

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Uplarafenib, CAS 1425485-87-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 213.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 997.00
100 mg	In stock	$ 1,730.00
500 mg	In stock	$ 3,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 235.00

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Purity: 99.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E [1].
B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, and less than 50 nM against BRAF V600E.[1]
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cell growth but not CHL-1 and SK-MEL-31 cells [1]. Cell Viability Assay.[1]
Cell Line: A375, SK-MEL-28, SK-MEL-31, and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.

Synonyms	B-Raf IN 10
Molecular Weight	494.49
Formula	C22H21F3N4O4S
CAS No.	1425485-87-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (182.00 mM), Sonication is recommended.

References and Literature

1. Yong-Liang Zhu, et al. Certain Chemical Entities, Compositions, and Methods. US20130053384 A1.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Effusanin A Pseudoginsenoside Rh2 RMC-0331 Cyclorasin 9A5 Raf inhibitor 2 SGX-523 BMS-214662 NVP-BAW2881

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Uplarafenib 1425485-87-5 MAPK Raf B-Raf IN 10 inhibitor inhibit

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