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TPPB

Name: TPPB
Brand: TargetMol
SKU: T17148
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17148Cas No. 497259-23-1

TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).

TPPB

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Purity: 98.00%

Catalog No. T17148Cas No. 497259-23-1

TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$163	-	In Stock
5 mg	$546	-	In Stock
10 mg	$787	-	In Stock
1 mL x 10 mM (in DMSO)	$589	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.00%

Appearance:Solid

Color:Yellow

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COA HNMR

Product Introduction

Bioactivity

Description	TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
Targets&IC50	PKC:11.9 nM (ki)
In vitro	TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells [1][2].
In vivo	TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and [1].

Chemical Properties

Molecular Weight	501.54
Formula	C₂₇H₃₀F₃N₃O₃
Cas No.	497259-23-1
Smiles	CC(C)[C@@H]1N(C)c2ccc(NC(=O)\C=C\C=C\c3ccc(cc3)C(F)(F)F)cc2C[C@@H](CO)NC1=O
Relative Density.	1.229 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (249.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9939 mL	9.9693 mL	19.9386 mL	99.6929 mL
5 mM	0.3988 mL	1.9939 mL	3.9877 mL	19.9386 mL
10 mM	0.1994 mL	0.9969 mL	1.9939 mL	9.9693 mL
20 mM	0.0997 mL	0.4985 mL	0.9969 mL	4.9846 mL
50 mM	0.0399 mL	0.1994 mL	0.3988 mL	1.9939 mL
100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.9969 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc