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10-Methoxycamptothecin
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Catalog No. T4S1951Cas No. 19685-10-0
10-Methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from *Camptotheca acuminata*, exhibits potent anti-cancer properties.
10-Methoxycamptothecin
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Purity: 98.36%
Catalog No. T4S1951Cas No. 19685-10-0
10-Methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from *Camptotheca acuminata*, exhibits potent anti-cancer properties.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | In Stock | In Stock | |
| 5 mg | $81 | In Stock | In Stock | |
| 10 mg | $129 | In Stock | In Stock | |
| 25 mg | $237 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.36%
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Product Introduction
10-Methoxycamptothecin AI Summary
10-Methoxycamptothecin demonstrates notable antileukemic and antitumor activities across various cell lines. Against P-388 leukemia cells in mice, it shows optimal antileukemic activity at a dose of 0.5 mg/kg with a T/C ratio of 145.0%, and the lowest toxicity was observed at 1.0 mg/kg. The therapeutic index for P-388 leukemia cells is 1.0. It also displays antitumor activity against P-338 leukemia in mice at a dose of 1.6 mg/kg, achieving a T/C value of 167.0%. Moreover, 10-Methoxycamptothecin is highly effective against human A549/ATCC and HT-29 cells with IC50 values of 40.0 nM and 76.0 nM, respectively, as measured by the SRB method. In broader cytotoxicity assays, it inhibits the growth of various human tumor cell lines, including those of breast, renal, lung, prostate, leukemia, melanoma, ovarian, colon, and central nervous system origins, with GI50 values ranging from 2.438 nM to 3013.01 nM. Its potent in vitro activity is reflected by an ED50 value of 0.02 μg/ml against 9KB cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 10-Methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from *Camptotheca acuminata*, exhibits potent anti-cancer properties. |
| Molecular Weight | 378.38 |
| Formula | C21H18N2O5 |
| Cas No. | 19685-10-0 |
| Smiles | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(OC)cc4cc3Cn1c2=O |
| Relative Density. | 1.5g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (21.14 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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