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IHMT-MST1-58

Name: IHMT-MST1-58
Brand: TargetMol
SKU: T62512
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T62512Cas No. 2414484-25-4

IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.

IHMT-MST1-58

🥰Excellent

Purity: 99.92%

Catalog No. T62512Cas No. 2414484-25-4

IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$247	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock
500 mg	$2,570	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.92%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.
Targets&IC50	MST2:652 nM, MST1:240 nM(kd), MST1:23 nM
In vitro	IHMT-MST1-58 (0.1-10 μM; 1-2 h) inhibits the phosphorylation of MST1 in vitro.[1] IHMT-MST1-58 (0.03, 0.1 and 0.3 μM; 48 h) exhibits a significant protective effect of β cells from the damage caused by inflammatory cytokines.[1]
In vivo	IHMT-MST1-58 (p.o, 50 mg/kg/day, QD) combined with metformin resulted in the reduction of fasting blood glucose, demonstrating the protective effect on β cells and decrease in hemoglobin A1c levels in the STZ-induced T1D/T2D mouse models.[1]

Chemical Properties

Molecular Weight	438.5
Formula	C₂₁H₂₂N₆O₃S
Cas No.	2414484-25-4
Smiles	CN1C=2C(N(C)C(=O)C1C3=C(C)C=CC=C3)=CN=C(NC4=CC=C(S(N)(=O)=O)C=C4)N2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (205.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2805 mL	11.4025 mL	22.8050 mL	114.0251 mL
5 mM	0.4561 mL	2.2805 mL	4.5610 mL	22.8050 mL
10 mM	0.2281 mL	1.1403 mL	2.2805 mL	11.4025 mL
20 mM	0.1140 mL	0.5701 mL	1.1403 mL	5.7013 mL
50 mM	0.0456 mL	0.2281 mL	0.4561 mL	2.2805 mL
100 mM	0.0228 mL	0.1140 mL	0.2281 mL	1.1403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc