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XY018

Name: XY018
Brand: TargetMol
SKU: T24213
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24213Cas No. 1873358-87-2

Alias XY-018, XY 018

XY018 is an orally available, selective and highly effective ROR-γ antagonist with antitumor activity, inhibits ROR-γ activity, inhibits tumor cell growth, and can be used to study drug-resistant prostate cancer.

XY018

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Purity: 99.96%

Catalog No. T24213Alias XY-018, XY 018Cas No. 1873358-87-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	-	In Stock
5 mg	$82	-	In Stock
10 mg	$118	-	In Stock
25 mg	$193	-	In Stock
50 mg	$286	-	In Stock
100 mg	$423	-	In Stock
200 mg	$629	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	XY018 is an orally available, selective and highly effective ROR-γ antagonist with antitumor activity, inhibits ROR-γ activity, inhibits tumor cell growth, and can be used to study drug-resistant prostate cancer.
Targets&IC50	RORα:7.57 μM (PME-1 (HEK293T)), RORγ:0.19 μM (PME-1 (HEK293T))
In vitro	METHODS: C4-2B cells were treated with XY018 (0.07, 0.15, 0.31, 0.62, 1.25, 2.5, 5, 10 μM for 4 days), the cell titer GLO reagent was added, and cell viability was measured by luminescence on a GLOMAX microplate luminometer according to the manufacturer's instructions. RESULTS:XY018 inhibited the growth and survival of C4-2B cells. [1]
In vivo	METHODS: XY018 (5 mg/kg, intraperitoneal injection, 5 times a week for 23 days) was used to treat xenograft tumor model mice generated using PCa cell lines with different characteristics (such as C4-2B expressing AR with mutant LBD, VCaP and AR-V7 with amplified AR genes, 22Rv1 expressing high levels of multiple AR variants, and AR-negative PC3), and tumor growth in mice was observed. RESULTS:XY018 inhibited CRPC tumor growth in mice. [1] METHODS: XY018 (10 mg/kg, oral; 2 mg/kg, intravenous) was used to treat SD rats and its pharmacokinetic characteristics were determined. RESULTS:XY018 showed good pharmacokinetic characteristics in rats, with the same bioavailability of 19%, and an intravenous half-life of 7.67 hours. [2]
Synonyms	XY-018, XY 018

Chemical Properties

Molecular Weight	516.37
Formula	C₂₃H₁₅F₇N₂O₄
Cas No.	1873358-87-2
Smiles	O=C(CC1=C([N+]([O-])=O)C=CC=C1)NC2=CC=C(C3=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C3F)C=C2
Relative Density.	1.496 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (154.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9366 mL	9.6830 mL	19.3660 mL	96.8298 mL
5 mM	0.3873 mL	1.9366 mL	3.8732 mL	19.3660 mL
10 mM	0.1937 mL	0.9683 mL	1.9366 mL	9.6830 mL
20 mM	0.0968 mL	0.4841 mL	0.9683 mL	4.8415 mL
50 mM	0.0387 mL	0.1937 mL	0.3873 mL	1.9366 mL
100 mM	0.0194 mL	0.0968 mL	0.1937 mL	0.9683 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc