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Telithromycin

Name: Telithromycin
Brand: TargetMol
SKU: T4543
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4543Cas No. 191114-48-4

Alias RU66647, RU 66647, HMR3647, HMR 3647

Telithromycin is a semisynthetic 14-membered macrolide antibiotic and erythromycin derivative that binds to the 50S subunit of the 70S bacterial ribosome, inhibits bacterial protein synthesis, and exhibits antimicrobial activity against a wide range of gram-positive and gram-negative bacteria for the treatment of mild to moderate respiratory infections.

Telithromycin

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Purity: 99.50%

Catalog No. T4543Alias RU66647, RU 66647, HMR3647, HMR 3647Cas No. 191114-48-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.50%

Appearance:Solid

Color:White

Resource Download

COA MS HNMR HPLC

Product Introduction

Bioactivity

Description	Telithromycin is a semisynthetic 14-membered macrolide antibiotic and erythromycin derivative that binds to the 50S subunit of the 70S bacterial ribosome, inhibits bacterial protein synthesis, and exhibits antimicrobial activity against a wide range of gram-positive and gram-negative bacteria for the treatment of mild to moderate respiratory infections.
In vitro	The in vitro antimicrobial activity of Telithromycin was determined using Methods such as broth microdilution, agar dilution, and E-test Methods. MIC distribution was homogeneous (MIC range, 0.003 to 0.25 μg/ml)[1]. However, its MIC50 and MIC90 against Mycobacterium avium complex were both greater than 16 μg/ml, indicating weaker in vitro antimicrobial activity [2].
In vivo	In mouse models, oral Telithromycin (3-26 mg/kg) demonstrated excellent efficacy against erythromycin-resistant sepsis and significant antibacterial activity against a range of pathogens. In the erythromycin-resistant Streptococcus pneumoniae model, the ED50 of Telithromycin was 6.5 mg/kg, comparable to the efficacy of azithromycin. At a dose of 100 mg/kg, the plasma Cmax reached 8.5 mg/L, with lung concentrations of 13.3 μg/g. The volume of distribution was similar to that in humans, with plasma and lung tissue half-lives of 2.5 hours and 2.8 hours, respectively[3].
Synonyms	RU66647, RU 66647, HMR3647, HMR 3647

Chemical Properties

Molecular Weight	812
Formula	C₄₃H₆₅N₅O₁₀
Cas No.	191114-48-4
Smiles	C[C@@]12[C@](N(CCCCN3C=C(N=C3)C=4C=CC=NC4)C(=O)O1)([C@@H](C)C(=O)[C@H](C)C[C@](OC)(C)[C@H](O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC)[H]
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

Ethanol: 30 mg/mL (36.95 mM), Sonication is recommended.

DMSO: 80 mg/mL (98.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2315 mL	6.1576 mL	12.3153 mL	61.5764 mL
5 mM	0.2463 mL	1.2315 mL	2.4631 mL	12.3153 mL
10 mM	0.1232 mL	0.6158 mL	1.2315 mL	6.1576 mL
20 mM	0.0616 mL	0.3079 mL	0.6158 mL	3.0788 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0246 mL	0.1232 mL	0.2463 mL	1.2315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc