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Cicaprost

Catalog No. T61526 CAS 94079-80-8

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist, which induces relaxation of the artery via concentration-dependent mechanisms. Its EC50 value, determined to be 5.8 nM [1], further highlights its potency.

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Cicaprost, CAS 94079-80-8

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist, which induces relaxation of the artery via concentration-dependent mechanisms. Its EC50 value, determined to be 5.8 nM [1], further highlights its potency.
In vitro	Cicaprost significantly inhibits the proliferation of human pulmonary artery smooth muscle cells (HPASMC) that is induced by fetal bovine serum (FBS), exhibiting considerable antiproliferative effects at a concentration of 30 nM [2]. Additionally, it promotes the production of [3H]cyclic AMP and [3H]inositol phosphate, with half-maximal effective concentration (EC50) values ranging from 1.5 to 22 nM for the former and 49 to 457 nM for the latter, excluding effects on SK-N-SH cells [3]. In a Cell Proliferation Assay [2] using HPASMC, across a range of concentrations from 10 pM to 10 μM, Cicaprost displayed a dose-dependent reduction in cell proliferation, achieving an EC50 of 24.1 nM.
In vivo	Cicaprost modifies pain perception and inflammatory responses by targeting the prostacyclin receptor; its absence in mice does not alter these effects. Specifically, intravenous administration of Cicaprost at a dosage of 1 μg/kg induces a significant decrease in blood pressure (approximately 30 mm Hg) in anesthetized wild-type mice. However, this hypotensive response is absent in IP-deficient mice, even when the dosage is increased to 10 μg/kg. This differential effect underscores the role of the prostacyclin receptor in mediating Cicaprost's cardiovascular activity.

Molecular Weight	374.47
Formula	C22H30O5
CAS No.	94079-80-8

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Cicaprost 94079-80-8 inhibitor inhibit

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