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Anti-2B4/CD244 Antibody (1B831)
😃Good
Catalog No. TMAY-00155
Alias SLAMF4, Nmrk, NKR2B4, NAIL, CD244 molecule, natural killer cell receptor 2B4, 2B4
Anti-2B4/CD244 Antibody (1B831) is a Rabbit antibody targeting 2B4/CD244. Anti-2B4/CD244 Antibody (1B831) can be used in WB,ELISA(Cap),IP.
Anti-2B4/CD244 Antibody (1B831)
Anti-2B4/CD244 Antibody (1B831)
😃Good
Catalog No. TMAY-00155Alias SLAMF4, Nmrk, NKR2B4, NAIL, CD244 molecule, natural killer cell receptor 2B4, 2B4
Anti-2B4/CD244 Antibody (1B831) is a Rabbit antibody targeting 2B4/CD244. Anti-2B4/CD244 Antibody (1B831) can be used in WB,ELISA(Cap),IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $93 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB, ELISA(Cap), IP Reactivity: Human |
| Alias | SLAMF4, Nmrk, NKR2B4, NAIL, CD244 molecule, natural killer cell receptor 2B4, 2B4 |
| Ig Type | Rabbit IgG |
| Clone | 1B831 |
| Reactivity | Human |
| Verified Activity | 1. Anti-2B4 rabbit monoclonal antibody at 1:500 dilution. -Lane A: Daudi Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:42 kDa. -Observed band size:28 kDa(We are unsure as to the identity of these extra bands.) 2. 2B4 was immunoprecipitated using: -Lane A:0.5 mg Daudi Whole Cell Lysate. -2 µL anti-2B4 rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-2B4 rabbit monoclonal antibody, at 1:200 dilution. -Secondary antibody: -Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 42 kDa. -Observed band size: 28 kDa |
| Application | WB,ELISA(Cap),IP |
| Recommended Dose | WB: 1:500-1:2000; IP: 1-4 μL/mg of lysate; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human 2B4 / CD244 (rh 2B4 / CD244; TMPY-01568; NP_057466.1; Met1-Arg221). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human 2B4 / CD244 protein (TMPY-01568) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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