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Anti-SREBP2 Polyclonal Antibody
(Synonyms: Sterol regulatory element-binding transcription factor 2, Sterol regulatory element-binding protein 2, Sterol Regulatory Element Binding Protein-2, SREBP-2, Srebf2_retired, SRBP2, SRBP 2, Processed sterol regulatory element-binding protein 2, MGC124823, Class D basic helix-loop-helix protein 2, bHLHd2) Copy Product Info
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Synonyms: Sterol regulatory element-binding transcription factor 2, Sterol regulatory element-binding protein 2, Sterol Regulatory Element Binding Protein-2, SREBP-2, Srebf2_retired, SRBP2, SRBP 2, Processed sterol regulatory element-binding protein 2, MGC124823, Class D basic helix-loop-helix protein 2, bHLHd2
Catalog No. TMAB-01775 Copy Product Info
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Anti-SREBP2 Polyclonal Antibody is a Rabbit antibody targeting SREBP2. Anti-SREBP2 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P.
Anti-SREBP2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Color:Transparent
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| Description | Anti-SREBP2 Polyclonal Antibody is a Rabbit antibody targeting SREBP2. Anti-SREBP2 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P. |
| Synonyms | Sterol regulatory element-binding transcription factor 2, Sterol regulatory element-binding protein 2, Sterol Regulatory Element Binding Protein-2, SREBP-2, Srebf2_retired, SRBP2, SRBP 2, Processed sterol regulatory element-binding protein 2, MGC124823, Class D basic helix-loop-helix protein 2, bHLHd2 |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Pig,Horse) |
| Application | |
| Recommended Dose | FCM=1 μg/Test; ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Processed sterol regulatory element-binding protein 2: Nucleus. |
| Tissue Specificity | Ubiquitously expressed in adult and fetal tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. |
| Immunogen | KLH conjugated synthetic peptide: human SREBP-2 |
| Antigen Species | Human |
| Gene Name | SREBF2 |
| Gene ID | |
| Protein Name | Sterol regulatory element-binding protein 2 |
| Uniprot ID | |
| Biology Area | Metabolism of lipids and lipoproteins,Cholesterol Metabolism,HLH / Leucine Zipper,Transcription Factors,Cholesterol Metabolism,Lipid metabolism,Cancer |
| Function | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. |
| Molecular Weight | Theoretical: 126 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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