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2-Benzoxazolinone

Name: 2-Benzoxazolinone
Brand: TargetMol
SKU: T5572
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5572Cas No. 59-49-4

Alias 2-Hydroxybenzoxazole, 2-Benzoxazolone, 1,3-Benzoxazol-2(3H)-one

2-Benzoxazolinone (2-Hydroxybenzoxazole) is found in cereals and cereal products. 2-Benzoxazolinone is found in rye seedlings.

2-Benzoxazolinone

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Purity: 99.84%

Catalog No. T5572Alias 2-Hydroxybenzoxazole, 2-Benzoxazolone, 1,3-Benzoxazol-2(3H)-oneCas No. 59-49-4

2-Benzoxazolinone (2-Hydroxybenzoxazole) is found in cereals and cereal products. 2-Benzoxazolinone is found in rye seedlings.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:Yellow to Black

Resource Download

COA HNMR HPLC

Product Introduction

2-Benzoxazolinone AI Summary

2-Benzoxazolinone exhibits a variety of bioactivities, including significant inhibitory effects on several enzymes and biological processes. It inhibits recombinant human cytochrome P450 1A2 with an IC50 of 370 µM and shows anti-inflammatory activity by reducing concanavalin A-induced histamine release in Wistar rat peritoneal mast cells, achieving 14.3% inhibition at 1000 µM. In seed germination assays, it demonstrates varying phytotoxicity against Abutilon theophrasti, significantly reducing seed germination at a 5 mM concentration. The compound also displays potent inhibitory activity against AmpC Beta-Lactamase (IC50: 562.3 nM), JMJD2A-Tudor Domain (IC50: 31.6 µM), and exhibits cytotoxic effects in SW480 colon adenocarcinoma cells (IC50: 290.9 nM). Additionally, 2-Benzoxazolinone inhibits MBNL1-poly(CUG) RNA binding with a potency of 100 µM and shows modest inhibition of recombinant human IDO1, reducing activity by 4% relative to control. It affects O-GlcNAc transferase activity and glycan expression in COS7 cells, with an IC50 of 11.9 µM in an assay measuring GlcNAc transfer to CKII peptide. Furthermore, it inhibits D-amino acid oxidase activity at 20 µM with a 26% inhibition rate. These multifaceted activities highlight 2-Benzoxazolinone's potential as a bioactive compound with diverse applications in biochemical and pharmacological research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Benzoxazolinone (2-Hydroxybenzoxazole) is found in cereals and cereal products. 2-Benzoxazolinone is found in rye seedlings.
Targets&IC50	L. donovani:40 μg/mL (LC50)
Synonyms	2-Hydroxybenzoxazole, 2-Benzoxazolone, 1,3-Benzoxazol-2(3H)-one

Chemical Properties

Molecular Weight	135.12
Formula	C₇H₅NO₂
Cas No.	59-49-4
Smiles	O=C1NC2=CC=CC=C2O1
Relative Density.	1.3124 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1.35 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.4008 mL	37.0041 mL	74.0083 mL	370.0414 mL
5 mM	1.4802 mL	7.4008 mL	14.8017 mL	74.0083 mL
10 mM	0.7401 mL	3.7004 mL	7.4008 mL	37.0041 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc