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EDC hydrochloride

Name: EDC hydrochloride
Brand: TargetMol
SKU: T19947
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19947Cas No. 25952-53-8

Alias EDC-HCl Crosslinker, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

EDC hydrochloride (EDC-HCl Crosslinker) is a water-soluble carbodiimide compound. EDC hydrochloride, as a condensing agent, forms peptide bonds through the condensation reaction of carboxyl and amino groups and can be used to synthesize peptides with specific sequences and functions. EDC hydrochloride can covalently bind haptens to carrier proteins to form immune antigens, which are used in vaccine research. EDC hydrochloride can react with the 5 'phosphate group of nucleic acids and is used for the labeling of DNA and RNA. EDC hydrochloride can cross-link proteins with nucleic acids and is used to prepare immune cross-links. EDC hydrochloride, as a crosslinking agent, connects the amine-reactive NHS ester of biomolecules with the carboxyl group, which can be used for protein coupling to create hybrid molecules with new properties and functions.

EDC hydrochloride

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Purity: 100%

Catalog No. T19947Alias EDC-HCl Crosslinker, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochlorideCas No. 25952-53-8

Pack Size	Price	Availability	Quantity
10 g	$32	In Stock

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Purity:100%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	EDC hydrochloride (EDC-HCl Crosslinker) is a water-soluble carbodiimide compound. EDC hydrochloride, as a condensing agent, forms peptide bonds through the condensation reaction of carboxyl and amino groups and can be used to synthesize peptides with specific sequences and functions. EDC hydrochloride can covalently bind haptens to carrier proteins to form immune antigens, which are used in vaccine research. EDC hydrochloride can react with the 5 'phosphate group of nucleic acids and is used for the labeling of DNA and RNA. EDC hydrochloride can cross-link proteins with nucleic acids and is used to prepare immune cross-links. EDC hydrochloride, as a crosslinking agent, connects the amine-reactive NHS ester of biomolecules with the carboxyl group, which can be used for protein coupling to create hybrid molecules with new properties and functions.
Targets&IC50	lysine:500 µM
In vitro	METHODS: Human fibroblasts were treated with EDC hydrochloride (0, 4, 8, 16, 24 mM) for 4, 6, and 24 hours, and the detection showed the cell survival rate. RESULTS: The cell survival rate decreased in a time-dependent manner with the concentration of EDC hydrochloride.
In vivo	METHODS: To study the effect of EDC hydrochloride on neurological function, EDC hydrochloride (0.0075%, once) was intramuscular injected into adult male Swiss Webster mice. RESULTS: EDC hydrochloride does not cause neurological deficits after injection. [1]
Synonyms	EDC-HCl Crosslinker, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

Chemical Properties

Molecular Weight	191.7
Formula	C₈H₁₈ClN₃
Cas No.	25952-53-8
Smiles	Cl.CCN=C=NCCCN(C)C
Relative Density.	0.877 g/cm3 at 20℃ (lit.)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30 mg/mL (156.49 mM)

DMSO: 55 mg/mL (286.91 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2165 mL	26.0824 mL	52.1648 mL	260.8242 mL
5 mM	1.0433 mL	5.2165 mL	10.4330 mL	52.1648 mL
10 mM	0.5216 mL	2.6082 mL	5.2165 mL	26.0824 mL
20 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0412 mL
50 mM	0.1043 mL	0.5216 mL	1.0433 mL	5.2165 mL
100 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6082 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EDC Hydrochloride