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Monardic acid A

Catalog No. TN13420 Copy Product Info
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Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE derived from electric eels. It shows weak inhibitory activity on human erythrocyte AChE (IC50>100 μM) and has no significant effect on BChE. By inhibiting AChE activity, Monardic acid A decreases acetylcholine breakdown while also inhibiting histamine release and hyaluronidase activity, contributing to its anti-inflammatory and neurotransmitter-regulating properties. It can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus) and is primarily used in the development of anti-inflammatory drugs and treatments for neurodegenerative diseases.

Monardic acid A

Copy Product Info
🥰Excellent
Catalog No. TN13420

Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE derived from electric eels. It shows weak inhibitory activity on human erythrocyte AChE (IC50>100 μM) and has no significant effect on BChE. By inhibiting AChE activity, Monardic acid A decreases acetylcholine breakdown while also inhibiting histamine release and hyaluronidase activity, contributing to its anti-inflammatory and neurotransmitter-regulating properties. It can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus) and is primarily used in the development of anti-inflammatory drugs and treatments for neurodegenerative diseases.

Monardic acid A
Cas No. 1607436-76-9
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE derived from electric eels. It shows weak inhibitory activity on human erythrocyte AChE (IC50>100 μM) and has no significant effect on BChE. By inhibiting AChE activity, Monardic acid A decreases acetylcholine breakdown while also inhibiting histamine release and hyaluronidase activity, contributing to its anti-inflammatory and neurotransmitter-regulating properties. It can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus) and is primarily used in the development of anti-inflammatory drugs and treatments for neurodegenerative diseases.
Chemical Properties
Molecular Weight538.46
FormulaC27H22O12
Cas No.1607436-76-9
SmilesC(O)(=O)[C@@H]1C=2C(O[C@H]1C3=CC(O)=C(O)C=C3)=C(O)C=CC2/C=C/C(O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O)=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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