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SS-208

Name: SS-208
Brand: TargetMol
SKU: T16936
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16936Cas No. 2245942-72-5

SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.

SS-208

🥰Excellent

Purity: 99.69%

Catalog No. T16936Cas No. 2245942-72-5

SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.

Pack Size	Price	Availability
1 mg	$53	In Stock
5 mg	$118	In Stock
10 mg	$188	In Stock
25 mg	$328	In Stock
50 mg	$472	In Stock
100 mg	$648	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.69%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
Targets&IC50	HDAC6:12 nM, HDAC8:1.23 μM, HDAC1:1.39 μM, HDAC11:5.12 μM, HDAC5:6.91 μM, HDAC7:8.34 μM
In vivo	In C57BL/6 mice injected immunogenic murine SM1 melanoma cells, SS-208 (25 mg/kg; i.p.) causes a significant reduction of the tumor growth[1].

Chemical Properties

Molecular Weight	344.15
Formula	C₁₃H₁₁Cl₂N₃O₄
Cas No.	2245942-72-5
Smiles	ONC(=O)c1cc(CCNC(=O)c2ccc(Cl)c(Cl)c2)on1
Relative Density.	1.507 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (290.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9057 mL	14.5285 mL	29.0571 mL	145.2855 mL
5 mM	0.5811 mL	2.9057 mL	5.8114 mL	29.0571 mL
10 mM	0.2906 mL	1.4529 mL	2.9057 mL	14.5285 mL
20 mM	0.1453 mL	0.7264 mL	1.4529 mL	7.2643 mL
50 mM	0.0581 mL	0.2906 mL	0.5811 mL	2.9057 mL
100 mM	0.0291 mL	0.1453 mL	0.2906 mL	1.4529 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc