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Dihydrolycorine
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Catalog No. T3S1729Cas No. 6271-21-2
1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. 3. Dihydrolycorine and nimodipine protects against anoxia damage of brain in rat.
Dihydrolycorine
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Purity: 99.85%
Catalog No. T3S1729Cas No. 6271-21-2
1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. 3. Dihydrolycorine and nimodipine protects against anoxia damage of brain in rat.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $29 | In Stock | In Stock | |
| 5 mg | $47 | In Stock | In Stock | |
| 10 mg | $82 | In Stock | In Stock | |
| 25 mg | $129 | In Stock | In Stock | |
| 50 mg | $197 | In Stock | In Stock | |
| 100 mg | $350 | - | In Stock | |
| 200 mg | $490 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.85%
Appearance:Solid
Color:White to Green
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Product Introduction
Dihydrolycorine AI Summary
Dihydrolycorine shows growth inhibition in a variety of human and mouse cell lines, including proapoptotic stimuli-resistant human A549, OE21, U373, and SK-MEL-28 cells, proapoptotic stimuli-sensitive human Hs683 cells, and mouse B16F10 cells, with an IC50 value greater than 10000.0 nM across all tested lines after 72 hours as measured by MTT assay. Additionally, this compound exhibits promising bioactivities with a high selectivity index, indicating a favorable IC50 ratio for Trypanosoma brucei rhodesiense compared to human KB cells. Its cytotoxicity profile reveals an IC50 value greater than 50.0 µg/mL for human KB cells and 26.99 µg/mL for rat L6 cells. Dihydrolycorine also demonstrates specific antitrypanosomal activity with an IC50 of 3.1 µg/mL against Trypanosoma brucei rhodesiense and an IC50 of 21.37 µg/mL against Trypanosoma cruzi, while showing limited activity against Leishmania donovani with an IC50 greater than 90.0 µg/mL..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. 3. Dihydrolycorine and nimodipine protects against anoxia damage of brain in rat. |
| Molecular Weight | 289.33 |
| Formula | C16H19NO4 |
| Cas No. | 6271-21-2 |
| Smiles | [H][C@@]12CCN3Cc4cc5OCOc5cc4[C@]([H])([C@H](O)[C@@H](O)C1)[C@@]23[H] |
| Relative Density. | 1.48 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.9 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.46 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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