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Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2
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Catalog No. TMAB-11387
Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TPH2 (Ser19). Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2
Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2
Copy Product Info😃Good
Catalog No. TMAB-11387
Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TPH2 (Ser19). Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TPH2 (Ser19). Anti-Phospho-TPH2 (Ser19) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Dog,Horse) |
| Verified Activity | Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-phospho-TPH2 (Ser19) Polyclonal Antibody, Unconjugated (TMAB-11387) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Brain specific. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and tryptophan hydroxylase 2 (TPH2) comprise a small family of monooxygenases that catalyze the rate-limiting step in the catabolism of aromatic L-amino acids and utilize tetrahydropterine as a cofactor. TPH2 is highly expressed in the central nervous system (CNS), mainly in the brain. TPH2 catalyzes the first step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland, and may be involved in the pathology of several neuropsychiatric disorders. Glucocorticoid-mediated reduction of TPH2 is associated with the etiology of mood disorders, specifically psychotic major depression, and TPH2 may be related to dysregulation of serotonin neurotransmission in the brain which commonly leads to suicidal behavior. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human TPH2 around the phosphorylation site of Ser19 |
| Antigen Species | Human |
| Gene Name | TPH2 |
| Gene ID | |
| Protein Name | Tryptophan 5-hydroxylase 2 |
| Uniprot ID |
| Molecular Weight | Theoretical: 56 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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