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CMK

Name: CMK
Brand: TargetMol
SKU: T10845
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T10845Cas No. 821794-90-5

CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.

CMK

🥰Excellent

Catalog No. T10845Cas No. 821794-90-5

CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Product Introduction

Bioactivity

Description	CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.
In vitro	CMK inhibits the growth of Cdc5 (L158G) with an IC50 of 36 nM, significantly more effective than its action on wild type Cdc5 (>30 μM). It causes a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain (IC50: 1.1 μM) and leads to anaphase arrest and delay in anaphase spindle migration.

Chemical Properties

Molecular Weight	358.82
Formula	C₁₈H₁₉ClN₄O₂
Cas No.	821794-90-5
Smiles	Cc1ccc(cc1)-c1c(C(=O)CCl)n(CCCO)c2ncnc(N)c12
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (418.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7869 mL	13.9346 mL	27.8691 mL	139.3456 mL
5 mM	0.5574 mL	2.7869 mL	5.5738 mL	27.8691 mL
10 mM	0.2787 mL	1.3935 mL	2.7869 mL	13.9346 mL
20 mM	0.1393 mL	0.6967 mL	1.3935 mL	6.9673 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7869 mL
100 mM	0.0279 mL	0.1393 mL	0.2787 mL	1.3935 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CMK

CMK

CMK