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CMK

🥰Excellent
Catalog No. T10845Cas No. 821794-90-5

CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.

CMK
Other Forms of CMK:

CMK

🥰Excellent
Catalog No. T10845Cas No. 821794-90-5
CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.
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Product Introduction

Bioactivity
Description
CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.
In vitro
CMK inhibits the growth of Cdc5 (L158G) with an IC50 of 36 nM, significantly more effective than its action on wild type Cdc5 (>30 μM). It causes a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain (IC50: 1.1 μM) and leads to anaphase arrest and delay in anaphase spindle migration.
Chemical Properties
Molecular Weight358.82
FormulaC18H19ClN4O2
Cas No.821794-90-5
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 150 mg/mL (418.04 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.2 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7869 mL13.9346 mL27.8691 mL139.3456 mL
5 mM0.5574 mL2.7869 mL5.5738 mL27.8691 mL
10 mM0.2787 mL1.3935 mL2.7869 mL13.9346 mL
20 mM0.1393 mL0.6967 mL1.3935 mL6.9673 mL
50 mM0.0557 mL0.2787 mL0.5574 mL2.7869 mL
100 mM0.0279 mL0.1393 mL0.2787 mL1.3935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CMK
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