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ND-322 HCl

Name: ND-322 HCl
Brand: TargetMol
SKU: T28145
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28145Cas No. 1333379-23-9

Alias ND-322 Hydrochloride, ND322 Hydrochloride, ND322 HCl, ND 322 Hydrochloride

ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.

ND-322 HCl

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Purity: 99.49%

Catalog No. T28145Alias ND-322 Hydrochloride, ND322 Hydrochloride, ND322 HCl, ND 322 HydrochlorideCas No. 1333379-23-9

ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$163	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$546	In Stock	In Stock
25 mg	$866	In Stock	In Stock
50 mg	$1,160	In Stock	In Stock
100 mg	$1,570	-	In Stock
1 mL x 10 mM (in DMSO)	$388	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.49%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

ND-322 HCl AI Summary

ND-322 HCl shows bioactivities related to drug metabolism in C57B1/6 mouse plasma, with a progressive conversion into the active form over varying time intervals. It exhibits specific pharmacokinetic properties, such as distribution half-life, terminal half-life, volume of distribution, and clearance when administered as a single bolus dose. Additionally, ND-322 HCl demonstrates considerable pharmacological behavior characterized by AUC values. The compound is a potent inhibitor of human MMP2 and MMP9 enzymes, with an IC50 of 63.6 nM for MMP2 and 611.0 nM for MMP9. At a concentration of 10 µM, it achieves complete inhibition of MMP2 (100.0%) and significant inhibition of MMP9 (96.7%), as determined by fluorometric analysis using specific substrates..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.
Synonyms	ND-322 Hydrochloride, ND322 Hydrochloride, ND322 HCl, ND 322 Hydrochloride

Chemical Properties

Molecular Weight	357.88
Formula	C₁₅H₁₆ClNO₃S₂
Cas No.	1333379-23-9
Smiles	Cl.O=S(=O)(C1=CC=C(OC2=CC=C(N)C=C2)C=C1)CC3SC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (125.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7942 mL	13.9712 mL	27.9423 mL	139.7116 mL
5 mM	0.5588 mL	2.7942 mL	5.5885 mL	27.9423 mL
10 mM	0.2794 mL	1.3971 mL	2.7942 mL	13.9712 mL
20 mM	0.1397 mL	0.6986 mL	1.3971 mL	6.9856 mL
50 mM	0.0559 mL	0.2794 mL	0.5588 mL	2.7942 mL
100 mM	0.0279 mL	0.1397 mL	0.2794 mL	1.3971 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc