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PIK-293

Name: PIK-293
Brand: TargetMol
SKU: T3348
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3348Cas No. 900185-01-5

Alias PIK293

PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.

PIK-293

🥰Excellent

Purity: 99.88%

Catalog No. T3348Alias PIK293Cas No. 900185-01-5

PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.

Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$59	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$289	In Stock
50 mg	$438	In Stock
100 mg	$635	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Batch Information

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Purity:99.88%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
Targets&IC50	PI3Kδ:0.24 μM, PI3Kα:100 μM, PI3Kβ:10 μM, PI3Kγ:25 μM
In vitro	PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine. [1]
Synonyms	PIK293

Chemical Properties

Molecular Weight	397.43
Formula	C₂₂H₁₉N₇O
Cas No.	900185-01-5
Smiles	Cc1ccccc1-n1c(Cn2ncc3c(N)ncnc23)nc2cccc(C)c2c1=O
Relative Density.	1.43 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 80 mg/mL (201.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5162 mL	12.5808 mL	25.1617 mL	125.8083 mL
5 mM	0.5032 mL	2.5162 mL	5.0323 mL	25.1617 mL
10 mM	0.2516 mL	1.2581 mL	2.5162 mL	12.5808 mL
20 mM	0.1258 mL	0.6290 mL	1.2581 mL	6.2904 mL
50 mM	0.0503 mL	0.2516 mL	0.5032 mL	2.5162 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc