Shopping Cart

Your shopping cart is currently empty

Zalcitabine

Name: Zalcitabine
Brand: TargetMol
SKU: T0110
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T0110Cas No. 7481-89-2

Alias Ro 24-2027/000, NSC 606170, Dideoxycytidine, ddC, 2',3'-Dideoxycytidine

Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.

Zalcitabine

Copy Product Info

😃Good

Purity: 99.92%

Catalog No. T0110Alias Ro 24-2027/000, NSC 606170, Dideoxycytidine, ddC, 2',3'-DideoxycytidineCas No. 7481-89-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$43	In Stock	In Stock
100 mg	$61	In Stock	In Stock
200 mg	$81	In Stock	In Stock
500 mg	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.
In vitro	Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) in both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by targeting reverse transcriptase and terminating the elongation of proviral DNA. Zalcitabine also inhibits the cellular uptake of [3H]-PAH in CHO/hOAT1 cells, with an IC50 value of 1.23 mM, and its uptake increases threefold with enhanced hOAT1 activity in these cells.
Synonyms	Ro 24-2027/000, NSC 606170, Dideoxycytidine, ddC, 2',3'-Dideoxycytidine

Chemical Properties

Molecular Weight	211.22
Formula	C₉H₁₃N₃O₃
Cas No.	7481-89-2
Smiles	O=C1N([C@@H]2O[C@H](CO)CC2)C=CC(N)=N1
Relative Density.	1.57 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 74 mg/mL (350.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7344 mL	23.6720 mL	47.3440 mL	236.7200 mL
5 mM	0.9469 mL	4.7344 mL	9.4688 mL	47.3440 mL
10 mM	0.4734 mL	2.3672 mL	4.7344 mL	23.6720 mL
20 mM	0.2367 mL	1.1836 mL	2.3672 mL	11.8360 mL
50 mM	0.0947 mL	0.4734 mL	0.9469 mL	4.7344 mL
100 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3672 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc