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Zalcitabine

Name: Zalcitabine
Brand: TargetMol
SKU: T0110
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0110Cas No. 7481-89-2

Alias Ro 24-2027/000, NSC 606170, Dideoxycytidine, ddC, 2',3'-Dideoxycytidine

Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.

Zalcitabine

🥰Excellent

Purity: 99.92%

Catalog No. T0110Alias Ro 24-2027/000, NSC 606170, Dideoxycytidine, ddC, 2',3'-DideoxycytidineCas No. 7481-89-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$43	In Stock	In Stock
100 mg	$61	In Stock	In Stock
200 mg	$81	In Stock	In Stock
500 mg	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.
In vitro	Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) in both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by targeting reverse transcriptase and terminating the elongation of proviral DNA. Zalcitabine also inhibits the cellular uptake of [3H]-PAH in CHO/hOAT1 cells, with an IC50 value of 1.23 mM, and its uptake increases threefold with enhanced hOAT1 activity in these cells.
Synonyms	Ro 24-2027/000, NSC 606170, Dideoxycytidine, ddC, 2',3'-Dideoxycytidine

Chemical Properties

Molecular Weight	211.22
Formula	C₉H₁₃N₃O₃
Cas No.	7481-89-2
Smiles	O=C1N([C@@H]2O[C@H](CO)CC2)C=CC(N)=N1
Relative Density.	1.57 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 74 mg/mL (350.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7344 mL	23.6720 mL	47.3440 mL	236.7200 mL
5 mM	0.9469 mL	4.7344 mL	9.4688 mL	47.3440 mL
10 mM	0.4734 mL	2.3672 mL	4.7344 mL	23.6720 mL
20 mM	0.2367 mL	1.1836 mL	2.3672 mL	11.8360 mL
50 mM	0.0947 mL	0.4734 mL	0.9469 mL	4.7344 mL
100 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3672 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc