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Gavestinel sodium

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Catalog No. T22798Cas No. 153436-38-5
Alias GV 150526A, Gavestinel sodium salt

Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavestinel is used in acute ischaemic stroke studies.

Gavestinel sodium

Gavestinel sodium

🥰Excellent
Purity: 99.04%
Catalog No. T22798Alias GV 150526A, Gavestinel sodium saltCas No. 153436-38-5
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavestinel is used in acute ischaemic stroke studies.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$89In Stock
10 mg$147In Stock
25 mg$248In Stock
50 mg$369In Stock
100 mg$543In Stock
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Purity:99.04%
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Product Introduction

Bioactivity
Description
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavestinel is used in acute ischaemic stroke studies.
Targets&IC50
NMDAR:8.5(pKi)
In vivo
Gavestinel (800 mg) was administered as a loading dose and followed by either 100 mg, 200 mg, or 400 mg maintenance doses given every 12 h for five doses. The mean terminal half-life ranged from 29 h to 56 h. Gavestinel was extensively bound to plasma protein (median percentage free <0.01). During gavestinel administration, some patients exhibited elevated levels of bilirubin, which may be the result of shared mechanisms of elimination (glucuronide conjugation and excretion in bile).[2]
SynonymsGV 150526A, Gavestinel sodium salt
Chemical Properties
Molecular Weight397.19
FormulaC18H11Cl2N2NaO3
Cas No.153436-38-5
SmilesO=C(NC1=CC=CC=C1)/C=C/C2=C(C([O-])=O)NC3=CC(Cl)=CC(Cl)=C23.[Na+]
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90.0 mg/mL (226.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5177 mL12.5884 mL25.1769 mL125.8843 mL
5 mM0.5035 mL2.5177 mL5.0354 mL25.1769 mL
10 mM0.2518 mL1.2588 mL2.5177 mL12.5884 mL
20 mM0.1259 mL0.6294 mL1.2588 mL6.2942 mL
50 mM0.0504 mL0.2518 mL0.5035 mL2.5177 mL
100 mM0.0252 mL0.1259 mL0.2518 mL1.2588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

NMDA receptoriGluRGV-150526GV150526GV 150526Gavestinel sodiumGavestinel
Related Tags: buy Gavestinel sodium | purchase Gavestinel sodium | Gavestinel sodium cost | order Gavestinel sodium | Gavestinel sodium chemical structure | Gavestinel sodium in vivo | Gavestinel sodium formula | Gavestinel sodium molecular weight
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