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Anti-Phospho-Girdin (Tyr1765) Antibody (9H891)
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Catalog No. TMAB-10738
Anti-Phospho-Girdin (Tyr1765) Antibody (9H891) is a Rabbit antibody targeting Phospho-Girdin (Tyr1765). Anti-Phospho-Girdin (Tyr1765) Antibody (9H891) can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-Girdin (Tyr1765) Antibody (9H891)
Anti-Phospho-Girdin (Tyr1765) Antibody (9H891)
😃Good
Catalog No. TMAB-10738
Anti-Phospho-Girdin (Tyr1765) Antibody (9H891) is a Rabbit antibody targeting Phospho-Girdin (Tyr1765). Anti-Phospho-Girdin (Tyr1765) Antibody (9H891) can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Girdin (Tyr1765) Antibody (9H891) is a Rabbit antibody targeting Phospho-Girdin (Tyr1765). Anti-Phospho-Girdin (Tyr1765) Antibody (9H891) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 9H891 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:200-1000; IHC-Fr: 1:200-1000; IF: 1:200-1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. |
| Tissue Specificity | Expressed ubiquitously. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| Immunogen | KLH conjugated synthesised phosphopeptide: human APE around the phosphorylation site of Ser1765 |
| Antigen Species | Human |
| Gene Name | CCDC88A |
| Gene ID | |
| Protein Name | Girdin |
| Uniprot ID | |
| Function | Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. |
| Molecular Weight | Theoretical: 206 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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