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Gliotoxin-13C13

Catalog No. T35773

Synonyms: Gliotoxin-13C13

Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).6Under reducing conditions, gliotoxin inhibits leukotriene A4hydrolase epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4synthesis in neutrophils and monocytes.7

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Gliotoxin-13C13, CAS N/A

Pack Size	Availability	Price/USD	Quantity
250 μg	35 days	$ 1,510.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

In vivo, gliotoxin (5 mg/kg) reduces LTB4plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of peritonitis induced by zymosan A . It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 μM, respectively).8

Synonyms	Gliotoxin-13C13
Molecular Weight	N/A

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Acetonitrile: 3 mg/mL

References and Literature

1. Kwon-Chung, K.J., and Sugui, J.A.What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?Med. Mycol.47(Suppl 1)S97-S103(2009) 2. Kroll, M., Arenzana-Seisdedos, F., Bachelerie, F., et al.The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasomeChem. Biol.6(10)689-698(1999) 3. Pahl, H.L., Krauss, B., Schulze-Osthoff, K., et al.The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κBJ. Exp. Med.183(4)1829-1840(1996) 4. Anselmi, K., Stolz, D.B., Nalesnik, M., et al.Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: Exacerbation by caspase and serine protease inhibitionJ. Hepatol.47(1)103-113(2007) 5. Orciuolo, E., Stanzani, M., Canestraro, M., et al.Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: Implications for the pathogenesis of invasive aspergillosisJ. Leukoc. Biol.82(4)839-848(2007) 6. Aljofan, M., Sganga, M.L., Lo, M.K., et al.Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitroVirol. J.6187(2009) 7. K?nig, Pace, S., Pein, H., et al.Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolaseCell. Chem. Biol.26(4)524-534(2019) 8. Vigushin, D.M., Mirsaidi, N., Brooke, G., et al.Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivoMed. Oncol.21(1)21-30(2004)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gliotoxin-13C13 Gliotoxin13C13 Gliotoxin-13C-13 Gliotoxin 13C13 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.