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Anti-TAL-1 Antibody (7H409) is a Mouse antibody targeting TAL-1. Anti-TAL-1 Antibody (7H409) can be used in WB,IP,IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $427 | 7-10 days |
Description | Anti-TAL-1 Antibody (7H409) is a Mouse antibody targeting TAL-1. Anti-TAL-1 Antibody (7H409) can be used in WB,IP,IF. |
Reactivity | Human,Mouse,Rat |
Application | |
Recommended Dose | WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIα, a serine/ threonine protein kinase known to modulate the activity of other βHLH transcription factors. |
Conjucates | Unconjugated |
Immunogen | Peptide |
Antigen Species | Peptide |
Uniprot ID |
Molecular Weight | Theoretical: 42 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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