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ONC-841
Catalog No. T9901A-1033 Copy Product Info
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ONC-841 is a humanized monoclonal antibody targeting Sialic acid-binding Ig-like lectin 10 (Siglec-10). Siglec-10 is an inhibitory receptor expressed on the surface of macrophages that triggers a "don't eat me" signal upon binding to CD24 on tumor cells, thereby inhibiting phagocytosis. ONC-841 specifically binds to Siglec-10 and blocks the CD24-Siglec-10 interaction, alleviating immune suppression and enhancing the phagocytic clearance of tumor cells by macrophages. This antibody is significant for immunotherapy research in solid tumors with high CD24 expression, such as ovarian and breast cancers.
ONC-841
Copy Product Info🥰Excellent
Catalog No. T9901A-1033
ONC-841 is a humanized monoclonal antibody targeting Sialic acid-binding Ig-like lectin 10 (Siglec-10). Siglec-10 is an inhibitory receptor expressed on the surface of macrophages that triggers a "don't eat me" signal upon binding to CD24 on tumor cells, thereby inhibiting phagocytosis. ONC-841 specifically binds to Siglec-10 and blocks the CD24-Siglec-10 interaction, alleviating immune suppression and enhancing the phagocytic clearance of tumor cells by macrophages. This antibody is significant for immunotherapy research in solid tumors with high CD24 expression, such as ovarian and breast cancers.
ONC-841
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | ONC-841 is a humanized monoclonal antibody targeting Sialic acid-binding Ig-like lectin 10 (Siglec-10). Siglec-10 is an inhibitory receptor expressed on the surface of macrophages that triggers a "don't eat me" signal upon binding to CD24 on tumor cells, thereby inhibiting phagocytosis. ONC-841 specifically binds to Siglec-10 and blocks the CD24-Siglec-10 interaction, alleviating immune suppression and enhancing the phagocytic clearance of tumor cells by macrophages. This antibody is significant for immunotherapy research in solid tumors with high CD24 expression, such as ovarian and breast cancers. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Siglec-10 |
| Isotype | IgG4SP-opti |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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