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(Iso)-RJW100

Name: (Iso)-RJW100
Brand: TargetMol
SKU: T64363
Rating: 4.5 (1 reviews)

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Catalog No. T64363Cas No. 1276664-61-9

(Iso)-RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.4 and 7.2, respectively.

(Iso)-RJW100

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Catalog No. T64363Cas No. 1276664-61-9

(Iso)-RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.4 and 7.2, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	Inquiry	Inquiry
5 mg	$268	Inquiry	Inquiry
10 mg	$394	Inquiry	Inquiry
25 mg	$592	Inquiry	Inquiry
50 mg	$828	Inquiry	Inquiry
100 mg	$1,130	Inquiry	Inquiry
500 mg	$2,260	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$287	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

(Iso)-RJW100 AI Summary

(Iso)-RJW100 exhibits agonist activity at the human SF-1 and LRH-1 receptors, with EC50 values of 63.1 nM for SF-1 and 398.11 nM for LRH-1, indicating its potency in activating these receptors. Additionally, the compound demonstrates peptide recruitment activity for DAX1 and TIF2 peptides, as observed in TR-FRET assays, with ratios of 0.77 and 0.67, respectively. These bioactivities suggest that (Iso)-RJW100 may hold potential therapeutic implications related to SF-1 and LRH-1 receptor modulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

(Iso)-RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.4 and 7.2, respectively.

Chemical Properties

Molecular Weight	386.57
Formula	C₂₈H₃₄O
Cas No.	1276664-61-9
Smiles	C(=C)([C@]12C(=C(CCCCCC)C[C@]1([C@@H](O)CC2)[H])C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.064 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (142.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5869 mL	12.9343 mL	25.8685 mL	129.3427 mL
5 mM	0.5174 mL	2.5869 mL	5.1737 mL	25.8685 mL
10 mM	0.2587 mL	1.2934 mL	2.5869 mL	12.9343 mL
20 mM	0.1293 mL	0.6467 mL	1.2934 mL	6.4671 mL
50 mM	0.0517 mL	0.2587 mL	0.5174 mL	2.5869 mL
100 mM	0.0259 mL	0.1293 mL	0.2587 mL	1.2934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc