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Melitracen hydrochloride

Name: Melitracen hydrochloride
Brand: TargetMol
SKU: T4274
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4274Cas No. 10563-70-9

Alias Thymeol hydrochloride, Melixeran

Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.

Melitracen hydrochloride

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Purity: 99.99%

Catalog No. T4274Alias Thymeol hydrochloride, MelixeranCas No. 10563-70-9

Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$62	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$118	In Stock	In Stock
200 mg	$173	In Stock	In Stock
500 mg	$293	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Melitracen hydrochloride AI Summary

Melitracen hydrochloride exhibits bioactivities as an inhibitor in various assays. It inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 33498.3 nM in the absence of CPT and 21136.0 nM in the presence of CPT. Additionally, it inhibits the binding or entry into cells for Lassa Virus with a potency of 17782.8 nM and for Marburg Virus with a potency of 4466.8 nM. Furthermore, it has been identified as a gametocytocidal compound with a potency of 15848.9 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.
Targets&IC50	D1:, D2:
Synonyms	Thymeol hydrochloride, Melixeran

Chemical Properties

Molecular Weight	327.90
Formula	C₂₁H₂₆ClN
Cas No.	10563-70-9
Smiles	Cl.CN(C)CC\C=C1\c2ccccc2C(C)(C)c2ccccc12
Relative Density.	1.046 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (152.49 mM), Sonication is recommended.

H2O: 198.2 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.0497 mL	15.2486 mL	30.4971 mL	152.4855 mL
5 mM	0.6099 mL	3.0497 mL	6.0994 mL	30.4971 mL
10 mM	0.3050 mL	1.5249 mL	3.0497 mL	15.2486 mL
20 mM	0.1525 mL	0.7624 mL	1.5249 mL	7.6243 mL
50 mM	0.0610 mL	0.3050 mL	0.6099 mL	3.0497 mL
100 mM	0.0305 mL	0.1525 mL	0.3050 mL	1.5249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc