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Anti-Beta-Amyloid 1-42 Antibody (6J263)
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Catalog No. TMAB-00226
Alias APP695, Amyloid Precursor Protein 695, Amyloid Precursor
Anti-Beta-Amyloid 1-42 Antibody (6J263) is a Mouse antibody targeting Beta-Amyloid 1-42. Anti-Beta-Amyloid 1-42 Antibody (6J263) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Beta-Amyloid 1-42 Antibody (6J263)
Anti-Beta-Amyloid 1-42 Antibody (6J263)
😃Good
Catalog No. TMAB-00226Alias APP695, Amyloid Precursor Protein 695, Amyloid Precursor
Anti-Beta-Amyloid 1-42 Antibody (6J263) is a Mouse antibody targeting Beta-Amyloid 1-42. Anti-Beta-Amyloid 1-42 Antibody (6J263) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Beta-Amyloid 1-42 Antibody (6J263) is a Mouse antibody targeting Beta-Amyloid 1-42. Anti-Beta-Amyloid 1-42 Antibody (6J263) can be used in WB,IHC-P,IHC-Fr,IF. |
| Alias | APP695, Amyloid Precursor Protein 695, Amyloid Precursor |
| Ig Type | IgG2b |
| Clone | 6J263 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | 1. Positive sample (left): Alzheimer/s Disease Brain Negative sample (right): Normal Human Brain Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with (beta-Amyloid (1-42)) Monoclona Antibody, Unconjugated (TMAB-00226) at 1:1000 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 2. 100 ng Aβ1-42 Peptide per Lane probed with beta-Amyloid (1-42) polyclonal antibody respectively, unconjugated (TMAB-00226) at 1:1000 dilution and 4°C overnight incubation. Followed by corresponding conjugated secondary antibody incubation at RT for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:500-5000; IHC-Fr: 1:500-5000; IF: 1:200-5000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease. |
| Immunogen | KLH conjugated synthetic peptide: human beta-Amyloid(1-42) |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Regulation,RNA Processing,DNA / RNA binding |
| Molecular Weight | Theoretical: 4.4 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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