Anti-TRAF2 Polyclonal Antibody 2 is a Rabbit antibody targeting TRAF2. Anti-TRAF2 Polyclonal Antibody 2 can be used in WB.

IgG

Human,Mouse,Rat

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human TRAF2

Human

TRAF2

TNF receptor-associated factor 2

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.