Cephradine monohydrate is an orally administered β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens. It is indicated for infections of the respiratory tract, urinary tract, skin, and other sites. Cephradine also inhibits TOPK and blocks ultraviolet-induced skin inflammation.

In HaCat and JB6 cells, Cephradine monohydrate (0.5, 1, and 2 mM, 2, 4, 6, and 12 hours) inhibited SUV-induced phosphorylation of p38, JNKs, and H2AX in a dose- and time-dependent manner, and suppressed the secretion of IL6 and TNF-α. [2]

Methods: The dorsal skin of adult Babl/c mice was topically applied with Cephradine monohydrate (100 mg/kg), followed by SUV (100 KJ/m²) irradiation to investigate the effect of Cephradine monohydrate on SUV-induced skin inflammation in mice.
Results: Cephradine monohydrate treatment significantly reduced the increase in epidermal thickness and immune cell infiltration in mouse skin after SUV (100 KJ/m²) irradiation. It also effectively inhibited the phosphorylation of p38, JNKs, and H2AX, as well as the secretion of IL-6 and TNF-α.[2]