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Jagged-1 (188-204) TFA(219127-21-6 free base)
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Catalog No. TP1293
Alias Jagged-1 (188-204) TFA
Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-alphaB activation.
Jagged-1 (188-204) TFA(219127-21-6 free base)
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Purity: 99.48%
Catalog No. TP1293Alias Jagged-1 (188-204) TFA
Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-alphaB activation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $235 | In Stock | In Stock | |
| 5 mg | $412 | In Stock | In Stock | |
| 10 mg | $613 | In Stock | In Stock | |
| 25 mg | $977 | In Stock | In Stock | |
| 50 mg | $1,320 | In Stock | In Stock | |
| 100 mg | $1,780 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.48%
Appearance:solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-alphaB activation. |
| In vitro | Jagged-1 (188-204) TFA (40 μM, 72 h) activates the Notch signaling pathway and induces fully differentiated maturation of human keratinocytes via NF-kappaB and PPARgamma. [2]
Jagged-1 (188-204) TFA (50 μM, 24 h) enhances store-operated Ca2+ inward flow in human pulmonary artery smooth muscle cells. [3] |
| Synonyms | Jagged-1 (188-204) TFA |
| Molecular Weight | 2221.37 |
| Formula | C95H128F3N25O28S3 |
| Smiles | O=C(O)C(F)(F)F.O=C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N |
| Relative Density. | no data available |
| Sequence | {Cys}{Asp}{Asp}{Tyr}{Tyr}{Tyr}{Gly}{Phe}{Gly}{Cys}{Asn}{Lys}{Phe}{Cys}{Arg}{Pro}{Arg} |
| Sequence Short | CDDYYYGFGCNKFCRPR |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: 45 mg/mL (20.26 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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