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TLR1

🥰Excellent
Catalog No. T13932Cas No. 566914-00-9

TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.

TLR1

TLR1

🥰Excellent
Purity: 98.7%
Catalog No. T13932Cas No. 566914-00-9
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$51In StockIn Stock
5 mg$125In StockIn Stock
10 mg$190In StockIn Stock
25 mg$308In StockIn Stock
50 mg$413In StockIn Stock
100 mg$571In StockIn Stock
200 mg$756In StockIn Stock
1 mL x 10 mM (in DMSO)$132In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.7%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
In vitro
In EL4 thymoma cells and in freshly isolated murine lymphocytes, TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in a concentration-dependent manner.
In vivo
TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.).
Chemical Properties
Molecular Weight302.41
FormulaC18H26N2O2
Cas No.566914-00-9
SmilesC([C@@H](NC(CCC1=CC=CC=C1)=O)[C@@H](C)C)(=O)N2CCCC2
Relative Density.no data available
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (99.2 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.61 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3068 mL16.5338 mL33.0677 mL165.3384 mL
5 mM0.6614 mL3.3068 mL6.6135 mL33.0677 mL
10 mM0.3307 mL1.6534 mL3.3068 mL16.5338 mL
20 mM0.1653 mL0.8267 mL1.6534 mL8.2669 mL
50 mM0.0661 mL0.3307 mL0.6614 mL3.3068 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TLR-1TLR1TLR 1MyD88Inhibitorinhibit
Related Tags: buy TLR1 | purchase TLR1 | TLR1 cost | order TLR1 | TLR1 chemical structure | TLR1 in vivo | TLR1 in vitro | TLR1 formula | TLR1 molecular weight
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