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Saroglitazar Magnesium

Name: Saroglitazar Magnesium
Brand: TargetMol
SKU: T12834
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12834Cas No. 1639792-20-3

Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM).

Saroglitazar Magnesium

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Purity: 99.40%

Catalog No. T12834Cas No. 1639792-20-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$135	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$343	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$591	-	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.40%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM).
Targets&IC50	PPARα:0.65 pM （EC50， HepG2 cell）, PPARγ:3 nM （EC50， HepG2 cell）
In vivo	In db/db mice, Saroglitazar (0.01-3 mg/kg per day, orally) treatment with 12-day causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with highly significant (91%) reduction in serum insulin and AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose.in Wistar rats and marmosets A 90-day repeated dose comparative study confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes[1].

Chemical Properties

Molecular Weight	901.43
Formula	C₅₀H₅₆MgN₂O₈S₂
Cas No.	1639792-20-3
Smiles	C(C)O1[Mg+2]2(O(CC)C(CC3=CC=C(OCCN4C(=CC=C4C)C5=CC=C(SC)C=C5)C=C3)C(=O)[O-]2)[O-]C(=O)C1CC6=CC=C(OCCN7C(=CC=C7C)C8=CC=C(SC)C=C8)C=C6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (124.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1093 mL	5.5467 mL	11.0935 mL	55.4674 mL
5 mM	0.2219 mL	1.1093 mL	2.2187 mL	11.0935 mL
10 mM	0.1109 mL	0.5547 mL	1.1093 mL	5.5467 mL
20 mM	0.0555 mL	0.2773 mL	0.5547 mL	2.7734 mL
50 mM	0.0222 mL	0.1109 mL	0.2219 mL	1.1093 mL
100 mM	0.0111 mL	0.0555 mL	0.1109 mL	0.5547 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc