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Anti-IRAK4 Antibody (3T950) (Synonyms: REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kin...)
Catalog No. TMAH-00637 Copy Product Info
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Anti-IRAK4 Antibody (3T950) is an antibody targeting IRAK4. Anti-IRAK4 Antibody (3T950) can be used in ELISA,FCM,WB.
Anti-IRAK4 Antibody (3T950)
Copy Product Info🥰Excellent
Catalog No. TMAH-00637
Synonyms REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4
Anti-IRAK4 Antibody (3T950) is an antibody targeting IRAK4. Anti-IRAK4 Antibody (3T950) can be used in ELISA,FCM,WB.
Anti-IRAK4 Antibody
(3T950)
(3T950)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-IRAK4 Antibody (3T950) is an antibody targeting IRAK4. Anti-IRAK4 Antibody (3T950) can be used in ELISA,FCM,WB. |
| Synonyms | REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4 |
| Ig Type | Rabbit IgG |
| Clone | 3T950 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: THP-1 whole cell lysate, U251 whole cell lysate -All lanes: IRAK4 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 52, 38 kDa -Observed band size: 55 kDa 2. Overlay histogram showing Jurkat cells stained with TMAH-00637 (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*10^6 cells) for 1 h at 4°C.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4°C. Control antibody (green line) was Rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | WB:1:500-1:5000; FCM:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human IRAK4 |
| Antigen Species | Human |
| Gene Name | IRAK4 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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