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Anti-IRAK4 Antibody (3T950)
(Synonyms: REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4) Copy Product Info
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Synonyms: REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4
Catalog No. TMAH-00637 Copy Product Info
🥰Excellent
Anti-IRAK4 Antibody (3T950) is an antibody targeting IRAK4. Anti-IRAK4 Antibody (3T950) can be used in ELISA,FCM,WB.
Anti-IRAK4 Antibody
(3T950)
(3T950)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-IRAK4 Antibody (3T950) is an antibody targeting IRAK4. Anti-IRAK4 Antibody (3T950) can be used in ELISA,FCM,WB. |
| Synonyms | REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4 |
| Ig Type | Rabbit IgG |
| Clone | 3T950 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB:1:500-1:5000; FCM:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human IRAK4 |
| Antigen Species | Human |
| Gene Name | IRAK4 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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