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(5Z,2E)-CU-3

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Catalog No. T10177Cas No. 1815598-71-0

(5Z,2E)-CU-3 is a potent and highly selective inhibitor of the DGKα isozyme with an IC50 value of 0.6 μM, competing with ATP and exhibiting a Km value of 0.48 mM. It specifically targets the catalytic region of DGKα without affecting the regulatory region and has demonstrated antitumor and immunogenic effects by promoting cancer cell apoptosis and T cell activation.

(5Z,2E)-CU-3
Other Forms of (5Z,2E)-CU-3:
CU-3T27099861123-84-4
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(5Z,2E)-CU-3

😃Good
Catalog No. T10177Cas No. 1815598-71-0
(5Z,2E)-CU-3 is a potent and highly selective inhibitor of the DGKα isozyme with an IC50 value of 0.6 μM, competing with ATP and exhibiting a Km value of 0.48 mM. It specifically targets the catalytic region of DGKα without affecting the regulatory region and has demonstrated antitumor and immunogenic effects by promoting cancer cell apoptosis and T cell activation.
Pack SizePriceAvailabilityQuantity
1 mg$416-8 weeks
5 mg$976-8 weeks
10 mg$1726-8 weeks
25 mg$3786-8 weeks
50 mg$6476-8 weeks
100 mg$9976-8 weeks
500 mg$1,9906-8 weeks
1 mL x 10 mM (in DMSO)$1076-8 weeks
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Product Introduction

Bioactivity
Description
(5Z,2E)-CU-3 is a potent and highly selective inhibitor of the DGKα isozyme with an IC50 value of 0.6 μM, competing with ATP and exhibiting a Km value of 0.48 mM. It specifically targets the catalytic region of DGKα without affecting the regulatory region and has demonstrated antitumor and immunogenic effects by promoting cancer cell apoptosis and T cell activation.
Targets&IC50
DGKα:0.6 μM
In vitro
(5Z,2E)-CU-3 induced apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells[1].
Chemical Properties
Molecular Weight392.47
FormulaC16H12N2O4S3
Cas No.1815598-71-0
Relative Density.1.58 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

DGKCU-3CU3CU 3Apoptosis(5Z,2E)CU3(5Z,2E) CU 3
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