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Anti-RANKL/TNFSF11/CD254 Antibody (1Y312)

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Catalog No. TMAY-01990
Alias tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254

Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) is a Mouse antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) can be used in ELISA.

Anti-RANKL/TNFSF11/CD254 Antibody (1Y312)

Anti-RANKL/TNFSF11/CD254 Antibody (1Y312)

😃Good
Catalog No. TMAY-01990Alias tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) is a Mouse antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) can be used in ELISA.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) is a Mouse antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) can be used in ELISA.
Aliastumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Ig Type
Monoclonal Mouse IgG1
Clone
1Y312
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RANKL/TNFSF11 (rh RANKL/TNFSF11; TMPY-03364; AAC51762.1;Gly64-Asp245). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. RANK and RANKL are key regulators of bone remodeling and regulate T cell/dendritic cell communications, and lymph node formation. Moreover, RANKL and RANK are expressed in mammary gland epithelial cells and control the development of a lactating mammary gland during pregnancy. Genetically, RANKL and RANK are essential for the development and activation of osteoclasts and bone loss in response to virtually all triggers tested. Inhibition of RANKL function via the natural decoy receptor osteoprotegerin (OPG, TNFRSF11B) prevents bone loss in postmenopausal osteoporosis and cancer metastases. Importantly, RANKL appears to be the pathogenetic principle that causes bone and cartilage destruction in arthritis. RANK-RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but crosstalk with other signaling pathways also fine-tunes bone homeostasis both in normal physiology and disease. In addition, RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human RANKL/TNFSF11 Protein (TMPY-03364)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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