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Anti-RANKL/TNFSF11/CD254 Antibody (1Y312)
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Catalog No. TMAY-01990
Alias tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) is a Mouse antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) can be used in ELISA.
Anti-RANKL/TNFSF11/CD254 Antibody (1Y312)
Anti-RANKL/TNFSF11/CD254 Antibody (1Y312)
😃Good
Catalog No. TMAY-01990Alias tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) is a Mouse antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (1Y312) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254 |
| Ig Type | Mouse IgG1 |
| Clone | 1Y312 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RANKL/TNFSF11 (rh RANKL/TNFSF11; TMPY-03364; AAC51762.1;Gly64-Asp245). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. RANK and RANKL are key regulators of bone remodeling and regulate T cell/dendritic cell communications, and lymph node formation. Moreover, RANKL and RANK are expressed in mammary gland epithelial cells and control the development of a lactating mammary gland during pregnancy. Genetically, RANKL and RANK are essential for the development and activation of osteoclasts and bone loss in response to virtually all triggers tested. Inhibition of RANKL function via the natural decoy receptor osteoprotegerin (OPG, TNFRSF11B) prevents bone loss in postmenopausal osteoporosis and cancer metastases. Importantly, RANKL appears to be the pathogenetic principle that causes bone and cartilage destruction in arthritis. RANK-RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but crosstalk with other signaling pathways also fine-tunes bone homeostasis both in normal physiology and disease. In addition, RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human RANKL/TNFSF11 Protein (TMPY-03364) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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