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Ethylhydrocupreine hydrochloride

Catalog No. T40417 CAS 3413-58-9

Synonyms: Optochin hydrochloride

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of 25.75 nM for Plasmodium falciparum. Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of 25.75 nM against Plasmodium falciparum.Ethylhydrocupreine hydrochloride is an agonist of Gallus gallus2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7).

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Ethylhydrocupreine hydrochloride Chemical Structure

Ethylhydrocupreine hydrochloride, CAS 3413-58-9

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.27%

Purity: 98.13%

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Description	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of 25.75 nM for Plasmodium falciparum. Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of 25.75 nM against Plasmodium falciparum.Ethylhydrocupreine hydrochloride is an agonist of Gallus gallus2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7).
Targets&IC50	P. falciparum:25.75 nM (IC50)
In vitro	The mutation rate towards Ethylhydrocupreine (Optochin) resistance in three capsulated S. pneumoniae strains (S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255, and S. pneumoniae ATCC 49619) was determined through fluctuation analysis. It was found that for these strains, subinhibitory concentrations of penicillin noticeably increased the mutation rate (measured as mutations per cell division) to Ethylhydrocupreine (Optochin) resistance, with an enhancement ranging from 2.1- to 3.1-fold [2].
In vivo	The highest tolerated dose of ethylhydrocupreine hydrochloride for guinea pigs by intrapleural injection is about 0.2 to 0.3 cc. of a 1:100 solution per 100 gm. of weight, corresponding to 2 to 3 cc. of solution or 0.02 to 0.03 gm. of the drug per kilo of weight. The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs [1] .

Synonyms	Optochin hydrochloride
Molecular Weight	376.92
Formula	C21H29ClN2O2
CAS No.	3413-58-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (132.65 mM), Sonication is recommended.

DMSO: 125 mg/mL (331.64 mM), Sonication is recommended.

References and Literature

1. J A Kolmer, et al. CHEMOTHERAPEUTIC STUDIES WITH ETHYLHYDROCUPREINE HYDROCHLORIDE IN EXPERIMENTAL PNEUMOCOCCUS PLEURITIS. J Exp Med. 1921 May 31;33(6):693-711. 2. Paulo R Cortes, et al. Subinhibitory Concentrations of Penicillin Increase the Mutation Rate to Optochin Resistance in Streptococcus Pneumoniae. J Antimicrob Chemother. 2008 Nov;62(5):973-7. 3. Nassira Mahmoudi, et al. Identification of New Antimalarial Drugs by Linear Discriminant Analysis and Topological Virtual Screening. J Antimicrob Chemother. 2006 Mar;57(3):489-97. 4. Antonella Di Pizio, et al. Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors. Front Mol Biosci. 2018 Jan 31;5:6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Bioactive Compound Library Anti-Bacterial Compound Library Bioactive Compounds Library Max

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Keywords

Ethylhydrocupreine hydrochloride 3413-58-9 Microbiology/Virology Antibacterial Parasite taste Optochin Hydrochloride ggTas2r1 Ethylhydrocupreine Hydrochloride bitter antimalarial inhibit ggTas2r7 Optochin bactericidal Antimicrobial Inhibitor S. pneumoniae Ethylhydrocupreine Optochin hydrochloride Bacterial ggTas2r2 inhibitor

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