HER2/ERBB2 Protein, Mouse, Recombinant (hFc)

Name: HER2/ERBB2 Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-02469
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Neu, mKIAA3023, l11Jus8, HER-2, HER2, erb-b2 receptor tyrosine kinase 2, Erbb-2, EGFR2, c-neu, c-erbB2) Copy Product Info

Synonyms: Neu, mKIAA3023, l11Jus8, HER-2, HER2, erb-b2 receptor tyrosine kinase 2, Erbb-2, EGFR2, c-neu, c-erbB2

Catalog No. TMPY-02469 Copy Product Info

HER2/ERBB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.7 kDa and the accession number is P70424.

Pack Size	Price	USA Stock	Global Stock
5 µg	$48	-	In Stock
10 µg	$75	-	In Stock
20 µg	$118	-	In Stock
50 µg	$229	-	In Stock
100 µg	$386	-	In Stock
200 µg	$682	7-10 days	7-10 days
500 µg	$1,430	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:92.1%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Measured by its ability to bind Anti-Erbb2 Antibody (Pertuzumab) in functional ELISA.
Description	HER2/ERBB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.7 kDa and the accession number is P70424.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P70424
Construction	A DNA sequence encoding the mouse ERBB2 (P70424) extracellular domain (Met 1-Thr 653) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Thr 23
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.2 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	Neu, mKIAA3023, l11Jus8, HER-2, HER2, erb-b2 receptor tyrosine kinase 2, Erbb-2, EGFR2, c-neu, c-erbB2
Research Background	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

96.7 kDa (predicted); 120-130 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.