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SKLB4771

Name: SKLB4771
Brand: TargetMol
SKU: T2051
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2051Cas No. 1370256-78-2

Alias FLT3-IN-1, FLT3-IN-1

SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.

SKLB4771

🥰Excellent

Purity: 99.74%

Catalog No. T2051Alias FLT3-IN-1, FLT3-IN-1Cas No. 1370256-78-2

SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.

Pack Size	Price	Availability
1 mg	$61	In Stock
2 mg	$89	In Stock
5 mg	$133	In Stock
10 mg	$197	In Stock
25 mg	$413	In Stock
50 mg	$618	In Stock
100 mg	$879	In Stock
500 mg	$1,790	In Stock
1 mL x 10 mM (in DMSO)	$159	In Stock

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Batch Information

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Purity:99.74%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.
Targets&IC50	FLT3:10 nM, FLT3 (ITD, MV4-11 cells):6 nM
Synonyms	FLT3-IN-1, FLT3-IN-1

Chemical Properties

Molecular Weight	537.66
Formula	C₂₅H₂₇N₇O₃S₂
Cas No.	1370256-78-2
Smiles	Cc1ccc(NC(=O)Nc2nnc(Sc3ncnc4cc(OCCCN5CCOCC5)ccc34)s2)cc1
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8599 mL	9.2996 mL	18.5991 mL	92.9956 mL
5 mM	0.3720 mL	1.8599 mL	3.7198 mL	18.5991 mL
10 mM	0.1860 mL	0.9300 mL	1.8599 mL	9.2996 mL
20 mM	0.0930 mL	0.4650 mL	0.9300 mL	4.6498 mL
50 mM	0.0372 mL	0.1860 mL	0.3720 mL	1.8599 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc