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STX-0119

Name: STX-0119
Brand: TargetMol
SKU: T60160
Price: 448 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60160Cas No. 851095-32-4

STX-0119 is a selective, orally active STAT3 dimerization inhibitor that suppresses STAT3 transcription with an IC50 of 74 μM.

STX-0119

😃Good

Purity: 99.61%

Catalog No. T60160Cas No. 851095-32-4

STX-0119 is a selective, orally active STAT3 dimerization inhibitor that suppresses STAT3 transcription with an IC50 of 74 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$58	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$187	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$448	In Stock	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	STX-0119 is a selective, orally active STAT3 dimerization inhibitor that suppresses STAT3 transcription with an IC50 of 74 μM.
Targets&IC50	STAT3:74 μM (STAT3 transcription)
In vitro	STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through direct interaction with the STAT3 protein, without affecting upstream regulators like JAK, in HEK293 and MDA-MB-468 cells, and reduces the expression of STAT3 target proteins[1].
In vivo	STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice, with plasma concentrations maintained above 100 μg/mL (>260 μM) 8 hours post-administration[1].

Chemical Properties

Molecular Weight	382.37
Formula	C₂₂H₁₄N₄O₃
Cas No.	851095-32-4
Smiles	C(NC=1OC(=NN1)C2=CC=CO2)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (143.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6153 mL	13.0763 mL	26.1527 mL	130.7634 mL
5 mM	0.5231 mL	2.6153 mL	5.2305 mL	26.1527 mL
10 mM	0.2615 mL	1.3076 mL	2.6153 mL	13.0763 mL
20 mM	0.1308 mL	0.6538 mL	1.3076 mL	6.5382 mL
50 mM	0.0523 mL	0.2615 mL	0.5231 mL	2.6153 mL
100 mM	0.0262 mL	0.1308 mL	0.2615 mL	1.3076 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc