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Proton pump

A proton pump is an integral membrane protein pump that builds up a proton gradient across a biological membrane.During evolution, proton pumps have arisen independently on multiple occasions. Thus, not only throughout nature but also within single cells, different proton pumps that are evolutionarily unrelated can be found. Proton pumps are divided into different major classes of pumps that use different sources of energy, have different polypeptide compositions and evolutionary origins.

  • Bafilomycin A1
    T674088899-55-2
    Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.
    • $287
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  • Esomeprazole Sodium
    T2686L161796-78-7
    Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
    • $41
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  • Caloxin 2A1 acetate
    T40437L
    Caloxin 2A1 acetate is an inhibitor of extracellular plasma membrane Ca2+-ATPase (PMCA) peptide. Caloxin 2A1 acetate inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate.
    • $50
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  • Lansoprazole sodium
    T21651226904-00-3
    Lansoprazole sodium (Lansoprazole (sodium)) is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease.
    • $65
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  • WY-47766
    T29164134217-27-9In house
    WY-47766 (OST-766) is a small molecule proton pump inhibitor that can be used to study postmenopausal osteoporosis.
    • $293 TargetMol
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  • Saviprazole
    T28665121617-11-6In house
    Saviprazole (Hoe-731), a proton pump inhibitor, is used potentially for treatment of gastric ulcer.
    • $143
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  • Abeprazan hydrochloride
    T102211902954-87-3In house
    Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activation. Abeprazan hydrochloride is a proton pump inhibitor (PPI) that acts by reducing gastric acid production and is used to treat gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers.
    • $94
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  • Bamaquimast
    T5449135779-82-7In house
    Bamaquimast (L 0042) is a proton pump inhibitor for the study of asthma-like immune system disorders and respiratory diseases.
    • $49
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  • Rabeprazole Sulfide
    T1734117977-21-6
    Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors.
    • $30
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  • Abscisic Acid
    T636821293-29-8
    Abscisic Acid (Dormin) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.
    • $89
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  • Omeprazole
    T075773590-58-6
    Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    • $40
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  • Lansoprazole
    T0674103577-45-3
    Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
    • $45
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  • (R)-Lansoprazole
    T1021138530-94-6
    (R)-Lansoprazole (T 168390) is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
    • $33
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  • Levolansoprazole
    T20714138530-95-7
    Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50: 82 μM). Both (R)- and (S)-lansoprazole are pharmacologically active with similar potencies.
    • $228
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  • S-Pantoprazole sodium trihydrate
    T811191416988-58-3
    S-Pantoprazole (sodium trihydrate), a variant of Pantoprazole, is pivotal in managing diseases associated with gastric acid secretion disorders, serving as a proton pump inhibitor [1].
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  • Omeprazole sulfide
    T268773590-85-9
    Omeprazole sulfide (Ufiprazole), a metabolite of Omeprazole, functions as a proton pump inhibitor.
    • $33
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  • Esomeprazole Magnesium
    T2686161973-10-0
    Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
    • $35
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  • Ilaprazole
    T1756L172152-36-2
    Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the development of reflux oesophagitis.
    • $39
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  • SCH28080
    T1686576081-98-6
    SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, anti-secretory and cytoprotective activity.
    • $47
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  • Vonoprazan Fumarate
    T21254881681-01-2
    Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5.
    • $40
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  • Omeprazole Sodium
    T2239195510-70-6
    Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazole Sodium shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole Sodium inhibits growth of Gram-positive and Gram-negative bacteria.
    • $41
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  • 5-Hydroxylansoprazole
    T14051131926-98-2
    5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, resulting in the formation of 5-Hydroxylansoprazole.
      7-10 days
      Inquiry
    • Omeprazole metabolite Omeprazole sulfone
      T1230988546-55-8
      Omeprazole sulfone is a metabolite of Omeprazole that inhibits the proton pump.
      • $42
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    • Ilaprazole sodium hydrate
      T782182322264-11-7
      Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research and acts as a potent inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) [1] [2].
      • $58
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    • Pumaprazole
      T16682158364-59-1
      Pumaprazole (BY-841) is an antagonist of a reversible proton pump.
      • $247
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    • Pantoprazole Sodium Hydrate
      T0161164579-32-2
      Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
      • $30
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    • Vonoprazan
      T8388881681-00-1
      Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis
      • $29
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    • Esomeprazole Magnesium trihydrate
      T8386217087-09-7
      Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis.Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
      • $36
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    • Chebulinic acid
      TQ018418942-26-2
      Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
      • $67
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    • Pantoprazole sodium
      T6929138786-67-1
      Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+ K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.
      • $50
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    • Diphyllin
      TN110322055-22-7
      Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt β-catenin signaling.
      • $133
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    • Zinc pyrithione
      T050213463-41-7
      Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.
      • $45
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    • Thonzonium Bromide
      T2188553-08-2
      Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo.
      • $30
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    • Tegoprazan
      T17030942195-55-3
      Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro).
      • $65
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    • EN6
      T111911808714-73-9
      EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
      • $39
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    • Rabeprazole sodium
      T1651117976-90-6
      Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
      • $30
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    • Esomeprazole
      T20626119141-88-7
      Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).
      • $57
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    • Tenatoprazole
      T6700113712-98-4
      Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
      • $47
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    • Pantoprazole
      T6928102625-70-7
      Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
      • $30
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    • Ilaprazole sodium
      T1756172152-50-0
      Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
      • $31
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