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Satraplatin

Name: Satraplatin
Brand: TargetMol
SKU: T7221
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7221Cas No. 129580-63-8

Alias JM216, BMY45594, BMS182751

Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.

Satraplatin

🥰Excellent

Purity: 98.25%

Catalog No. T7221Alias JM216, BMY45594, BMS182751Cas No. 129580-63-8

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$648	In Stock
50 mg	$892	In Stock
100 mg	$1,230	In Stock

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Purity:98.25%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
In vitro	KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].
Cell Research	CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].
Synonyms	JM216, BMY45594, BMS182751

Chemical Properties

Molecular Weight	500.28
Formula	C₁₀H₂₂Cl₂N₂O₄Pt
Cas No.	129580-63-8
Smiles	[Pt+4]([NH2]C1CCCCC1)([O-]C(C)=O)([O-]C(C)=O)([Cl-])([Cl-])[NH3]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (65.96 mM), DMSO inactivates the activity of Satraplatin.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9989 mL	9.9944 mL	19.9888 mL	99.9440 mL
5 mM	0.3998 mL	1.9989 mL	3.9978 mL	19.9888 mL
10 mM	0.1999 mL	0.9994 mL	1.9989 mL	9.9944 mL
20 mM	0.0999 mL	0.4997 mL	0.9994 mL	4.9972 mL
50 mM	0.0400 mL	0.1999 mL	0.3998 mL	1.9989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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