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Satraplatin

Name: Satraplatin
Brand: TargetMol
SKU: T7221
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7221Cas No. 129580-63-8

Alias JM216, BMY45594, BMS182751

Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.

Satraplatin

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Purity: 98.25%

Catalog No. T7221Alias JM216, BMY45594, BMS182751Cas No. 129580-63-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$648	In Stock	In Stock
50 mg	$892	In Stock	In Stock
100 mg	$1,230	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.25%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
In vitro	KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].
Cell Research	CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].
Synonyms	JM216, BMY45594, BMS182751

Chemical Properties

Molecular Weight	500.28
Formula	C₁₀H₂₂Cl₂N₂O₄Pt
Cas No.	129580-63-8
Smiles	[Pt+4]([NH2]C1CCCCC1)([O-]C(C)=O)([O-]C(C)=O)([Cl-])([Cl-])[NH3]
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (65.96 mM), DMSO inactivates the activity of Satraplatin.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9989 mL	9.9944 mL	19.9888 mL	99.9440 mL
5 mM	0.3998 mL	1.9989 mL	3.9978 mL	19.9888 mL
10 mM	0.1999 mL	0.9994 mL	1.9989 mL	9.9944 mL
20 mM	0.0999 mL	0.4997 mL	0.9994 mL	4.9972 mL
50 mM	0.0400 mL	0.1999 mL	0.3998 mL	1.9989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc